Overview of paediatric tuberculosis cases treated in the Sydney Children's Hospitals Network, Australia

Laila S Al Yazidi, Ben J Marais, Meredith Wickens, Pamela Palasanthiran, David Isaacs, Alexander Outhred, Brendan McMullan, Philip N Britton

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


BACKGROUND: Sydney has a large and highly mobile immigrant community. The pattern of paediatric tuberculosis (TB) disease in this highly cosmopolitan city is not well documented.

METHODS: We reviewed data on all children notified with TB in New South Wales (NSW), Australia, from January 2014 to December 2015, complemented by an expanded dataset for children managed within the Sydney Children's Hospitals Network (SCHN).

RESULTS: Over the 2-year study period, 921 TB cases were identified in NSW, including 26 (2.8%) children younger than 15 years of age. Of 23 children and adolescents treated for TB in the SCHN, 21 (91.3%) had a history of recent immigration from, or travel to, a country with high TB incidence, and 7 (30.4%) reported contact with an infectious TB case in Australia. Fourteen (60.9%) children had microbiologically confirmed TB; of these, 5 (21.7%) had acid-fast bacilli on microscopy, 8 (34.8%) were positive by polymerase chain reaction and 11 (47.8%) were positive by culture. All Mycobacterium tuberculosis isolates were susceptible to first-line drugs. Ten (43.5%) cases were not vaccinated with bacille Calmette-Guérin (BCG), including all cases with severe disease: 2 with disseminated (miliary) TB and 3 with tuberculous meningitis.

CONCLUSION: Our findings emphasise the need for improved TB prevention and surveillance in children at high risk of exposure, particularly young children travelling to areas of high TB incidence.

Original languageEnglish
JournalPublic Health Research and Practice
Issue number2
Publication statusPublished - Jul 31 2019


  • Adolescent
  • Child
  • Child, Preschool
  • Emigrants and Immigrants/statistics & numerical data
  • Female
  • Hospitals, Pediatric/statistics & numerical data
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • New South Wales/epidemiology
  • Tuberculosis/epidemiology

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