One-Year Outcomes for Patients Undergoing Transcatheter Aortic Valve Replacement: The Gulf TAVR Registry

Mirvat Alasnag, Khaled AlMerri, Abdulrahman Almoghairi, Abdullah Alenezi, Fawaz Bardooli, Shereen Al-Sheikh, Nouf Alanazi, Waleed AlHarbi, Hatim Al Lawati, Khalid Al Faraidy, Mohammed AlShehri, Michael Thabane, Lehana Thabane, Khaled Al-Shaibi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: The use of transcatheter aortic valve replacement (TAVR) is steadily increasing with TAVR procedures offered to patients across the entire spectrum of surgical risks. The Gulf TAVR registry captures the demographics of patients undergoing TAVR in the Gulf region, comorbidities that drive outcomes, procedural success, complications, and one-year outcomes of death or rehospitalization. Methods: This is a retrospective cohort study for adult patients aged at least 18 years undergoing TAVR at eight centers in the Gulf region. The primary outcome was a composite of death or re-hospitalization at one-year. Secondary outcomes included the individual components of the composite, stroke, and myocardial infarction (MI). We used multivariable Cox regression to determine factors associated with the composite endpoint. Results: A total of 795 patients (56% male) were included in the final analysis with a mean age of 74.6 (standard deviation (SD) 8.9) years, Society of Thoracic Surgeons Score (STS) Score 4.9 (4.2), ejection fraction of 53% (12.7%). Transfemoral approach was employed in over 95% (762/795). The primary outcomes rate was 12.8% (95% confidence interval [CI]: 10.6–15.4); secondary endpoints were death 5.4% (95% CI 4.0–7.2); stroke 0.8% (95% CI 0.3, 1.7), MI 0.8% (95% CI 0.4–1.9), rehospitalization: 9.3% (95% CI 7.5–11.5) of whom 71.6% were related to cardiovascular causes. 77% of the cardiovascular admissions were attributable to heart failure or the need for pacemaker implantation. Stage IV or V chronic kidney disease was significantly associated with the primary composite endpoint (Hazard Ratio: 2.49, [95% CI: 1.31, 4.73], p = 0.005). Although not significant, paravalvular leak and severe left ventricular dysfunction showed a 2-fold and 3-fold increased risk for the composite endpoint, respectively. Conclusions: The Gulf TAVR registry is the first of its kind in the region. It profiles an elderly population with a high procedural success rate and a low rate of complications. One-year outcomes were primarily driven by repeat hospitalization for heart failure and pacemaker implantation indicating a need to optimize heart failure management and improve algorithms for the detection of conduction abnormalities.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalCardiovascular Revascularization Medicine
Publication statusPublished - Aug 2022


  • Aortic stenosis
  • Cardiovascular outcomes
  • STS score
  • TAVR

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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