Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases

Fatemeh Zahedipour, Paul C. Guest, Muhammed Majeed, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Statins have pleiotropic effects on inflammatory responses in addition to their lipid-lowering action, which contributes to their favorable effect on cardiovascular disorders. Statins affect adhesion, migration, antigen presentation, and cytokine generation of immune cells. Pre-clinical and clinical studies suggest that statin intervention targeted early in the infection might help COVID-19 patients to reduce the effects of acute respiratory distress syndrome (ARDS), the cytokine storm, and vascular collapse by modulating harmful pathogenic mechanisms. This chapter presents a protocol for measuring blood-based biomarkers predictive of these responses in COVID-19 patients using two specific multiplex immunoassays that target proteins that differ widely in concentration.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages12
Publication statusPublished - Jan 1 2022

Publication series

NameMethods in molecular biology (Clifton, N.J.)
PublisherHumana Press
ISSN (Print)1064-3745


  • C-reactive protein
  • COVID-19
  • IL-6
  • IL-8
  • Multiplex immunoassay
  • SARS-CoV-2
  • Simvastatin
  • Statins
  • TNF-α
  • Von Willebrand factor
  • Cytokine Release Syndrome
  • Severity of Illness Index
  • COVID-19 Drug Treatment
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'Multiplex Testing of the Effect of Statins on Disease Severity Risk in COVID-19 Cases'. Together they form a unique fingerprint.

Cite this