TY - JOUR
T1 - Morbidity and mortality of acute heart failure patients stratified by mitral regurgitation in the Arabian Gulf
T2 - Observations from the Gulf acute heart failure registry (Gulf CARE)
AU - AlObaid, Laura
AU - Rajan, Rajesh
AU - Al Jarallah, Mohammed
AU - Dashti, Raja
AU - Bulbanat, Bassam
AU - Ridha, Mustafa
AU - Sulaiman, Kadhim
AU - Al-Zakwani, Ibrahim
AU - Alsheikh-Ali, Alawi A.
AU - Panduranga, Prashanth
AU - AlHabib, Khalid F.
AU - Al Suwaidi, Jassim
AU - Al-Mahmeed, Wael
AU - AlFaleh, Hussam
AU - Elasfar, Abdelfatah
AU - Al-Motarreb, Ahmed
AU - Bazargani, Nooshin
AU - Asaad, Nidal
AU - Amin, Haitham
AU - Kobalava, Zhanna
AU - Brady, Peter A.
AU - Baca, Georgiana Luisa
AU - Al-Saber, Ahmad
N1 - © 2023 Published by Elsevier Ltd.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - This study aimed to evaluate the clinical outcomes of patients with acute heart failure (AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf CARE registry were identified from 47 hospitals in seven Arabian Gulf countries (Yemen, Oman, Kuwait, Qatar, Bahrain, the United Arab Emirates, and Saudi Arabia) from February to November 2012. The cohort was stratified into two groups based on the presence of MR. Univariable and multivariable statistical analyses were performed. The population cohort included 5005 consecutive patients presenting with AHF, of whom 1491 (29.8 %) had concomitant MR. The mean age of patients with AHF and concomitant MR was 59.2 ± 14.9 years, and 63.1 % (n = 2886) were male. A total of 58.6 % (n = 2683) had heart failure (HF) with reduced ejection fraction (EF) (HFrEF), 21.0 % (n = 961) had HF with mildly reduced EF (HFmrEF), and 20.4 % (n = 932) had HF with preserved EF (HFpEF). Patients with MR had a lower haemoglobin (Hb) level (12.4 vs. 12.7 g/dL; p < 0.001), and a higher prevalence of left atrial enlargement (80.2 % vs. 55.1 %; p < 0.001), cardiogenic shock (9.7 % vs. 7.3 %; p = 0.006) and atrial fibrillation (7.6 % vs. 5.6 %; p = 0.006), and HFrEF (71.0 % vs. 52.6 %; P < 0.001). Multivariable analysis demonstrated that MR was independently associated with increased all-cause mortality at 1-year and 3-month HF rehospitalization [1-year all-cause mortality, adjusted odds ratio (aOR), 1.40; 95 % confidence interval (Cl): 1.13–1.74; p = 0.002; 3-month HF rehospitalization, aOR, 1.26; 95 % Cl: 1.06–1.49; p = 0.009]. In an Arabian Gulf cohort with AHF, concomitant MR was associated with an increased risk of 1-year mortality and 3-months HF rehospitalization.
AB - This study aimed to evaluate the clinical outcomes of patients with acute heart failure (AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf CARE registry were identified from 47 hospitals in seven Arabian Gulf countries (Yemen, Oman, Kuwait, Qatar, Bahrain, the United Arab Emirates, and Saudi Arabia) from February to November 2012. The cohort was stratified into two groups based on the presence of MR. Univariable and multivariable statistical analyses were performed. The population cohort included 5005 consecutive patients presenting with AHF, of whom 1491 (29.8 %) had concomitant MR. The mean age of patients with AHF and concomitant MR was 59.2 ± 14.9 years, and 63.1 % (n = 2886) were male. A total of 58.6 % (n = 2683) had heart failure (HF) with reduced ejection fraction (EF) (HFrEF), 21.0 % (n = 961) had HF with mildly reduced EF (HFmrEF), and 20.4 % (n = 932) had HF with preserved EF (HFpEF). Patients with MR had a lower haemoglobin (Hb) level (12.4 vs. 12.7 g/dL; p < 0.001), and a higher prevalence of left atrial enlargement (80.2 % vs. 55.1 %; p < 0.001), cardiogenic shock (9.7 % vs. 7.3 %; p = 0.006) and atrial fibrillation (7.6 % vs. 5.6 %; p = 0.006), and HFrEF (71.0 % vs. 52.6 %; P < 0.001). Multivariable analysis demonstrated that MR was independently associated with increased all-cause mortality at 1-year and 3-month HF rehospitalization [1-year all-cause mortality, adjusted odds ratio (aOR), 1.40; 95 % confidence interval (Cl): 1.13–1.74; p = 0.002; 3-month HF rehospitalization, aOR, 1.26; 95 % Cl: 1.06–1.49; p = 0.009]. In an Arabian Gulf cohort with AHF, concomitant MR was associated with an increased risk of 1-year mortality and 3-months HF rehospitalization.
KW - Acute heart failure
KW - HF rehospitalization
KW - Mitral regurgitation
KW - Mortality
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UR - http://www.scopus.com/inward/citedby.url?scp=85177875219&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/5d4186b7-5a09-33e0-aeec-b18d86ac3787/
U2 - 10.1016/j.heliyon.2023.e22175
DO - 10.1016/j.heliyon.2023.e22175
M3 - Article
C2 - 38076138
AN - SCOPUS:85177875219
SN - 2405-8440
VL - 9
JO - Heliyon
JF - Heliyon
IS - 12
M1 - e22175
ER -