Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic health

The CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease (CVD) often cluster together as “Cardiometabolic Disease” (CMD). Just under 50% of patients with CMD increased the risk of morbidity and mortality right from the beginning of the COVID-19 pandemic as it has been reported in most countries affected by the SARS-CoV2 virus. One of the pathophysiological hallmarks of COVID-19 is the overactivation of the immune system with a prominent IL-6 response, resulting in severe and systemic damage involving also cytokines such as IL2, IL4, IL8, IL10, and interferon-gamma were considered strong predictors of COVID-19 severity. Thus, in this mini-review, we try to describe the inflammatory state, the alteration of the adipokine profile, and cytokine production in the obese state of infected and not infected patients by SARS-CoV2 with the final aim to find possible influences of COVID-19 on CMD and CVD. The immunological-based discussion of the molecular processes could inspire the study of promising targets for managing CMD patients and its complications during COVID-19.

Original languageEnglish
Article number166559
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1868
Issue number12
DOIs
Publication statusPublished - Dec 1 2022

Keywords

  • COVID
  • Cardiometabolic
  • Diabetes
  • Inflammation
  • Molecular
  • Interferon-gamma
  • Interleukin-4
  • Interleukin-2
  • Pandemics
  • Cytokines
  • Interleukin-10
  • Cardiovascular Diseases/epidemiology
  • Humans
  • Adipokines
  • Diabetes Mellitus, Type 2/complications
  • Interleukin-8
  • Interleukin-6
  • COVID-19
  • SARS-CoV-2
  • RNA, Viral
  • Obesity/complications

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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