TY - JOUR
T1 - Micro-ribonucleic acid and carcinogenesis
T2 - Breast cancer as an example
AU - Al-Khanbashi, Manal
AU - Al-Moundhri, Mansour
N1 - Publisher Copyright:
© Copyright M. Al-Khanbashi and M. Al-Moundhri et al., 2015.
PY - 2015
Y1 - 2015
N2 - MicroRNAs (miRNAs) are a class of small non-coding RNAs that have unique functions at post-transcriptional level (epigenetics). MiRNAs play a pivotal role in controlling gene expression at various levels including differentiation, cell-cycle regulation, apoptosis and many others in mammals as well as in many organisms. Recently, there has been greater understanding of the contribution of dysregulation of miRNA into disease status in particular carcinogenesis. In this review, we will discuss miRNA discovery, nomenclature, function, contribution of their dysregulation into disease status in particular carcinogenesis and their potential role as biomarkers.
AB - MicroRNAs (miRNAs) are a class of small non-coding RNAs that have unique functions at post-transcriptional level (epigenetics). MiRNAs play a pivotal role in controlling gene expression at various levels including differentiation, cell-cycle regulation, apoptosis and many others in mammals as well as in many organisms. Recently, there has been greater understanding of the contribution of dysregulation of miRNA into disease status in particular carcinogenesis. In this review, we will discuss miRNA discovery, nomenclature, function, contribution of their dysregulation into disease status in particular carcinogenesis and their potential role as biomarkers.
KW - Breast cancer
KW - Neo-adjuvant chemotherapy
KW - miRNA
UR - http://www.scopus.com/inward/record.url?scp=84981173263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981173263&partnerID=8YFLogxK
U2 - 10.4081/oncol.2015.279
DO - 10.4081/oncol.2015.279
M3 - Review article
C2 - 26779312
AN - SCOPUS:84981173263
SN - 1970-5557
VL - 9
SP - 28
EP - 34
JO - Oncology Reviews
JF - Oncology Reviews
IS - 1
ER -
