Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

M. O.M. Tanira*, B. H. Ali, A. K. Bashir, S. Dhanasekaran, E. M. Tibiricá, L. M. Alves

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalPharmacological Research
Issue number3
Publication statusPublished - 2000


  • Central
  • Hypotensive
  • Intracerebroventricular (icv)
  • Pithed
  • Rat
  • Rhazya stricta

ASJC Scopus subject areas

  • Pharmacology


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