Management and prevention of cytomegalovirus infection in paediatric hematopoietic stem cell transplant (HSCT) recipients: A binational survey

Laila S Al Yazidi, Richard Mitchell, Pamela Palasanthiran, Tracey A O'Brien, Brendan McMullan

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

CMV infection is an important cause of morbidity and mortality among HSCT recipients. Optimal strategies for prevention and management of CMV disease following haematopoietic stem cell transplantation remain uncertain. We conducted an online survey of Australasian paediatric allogeneic HSCT centres on management and prevention of CMV disease in this patient group. We asked for one response from a representative of the HSCT team and one from a representative of the ID team at each centre. All Australasian paediatric HSCT centres responded to our survey. Management of CMV in pre-transplant setting was consistent between centres. All centres used a pre-emptive strategy to prevent CMV disease, guided by quantitative CMV PCR. In the post-transplant post engraftment setting, all centres recommended using ganciclovir (5mg/kg/dose twice daily) as a first-line therapy for CMV reactivation or disease, with treatment duration of 14 days, provided declining CMV quantitative PCR. There was substantial variability of practice between centres in post-transplant management of CMV reactivation, especially during the pre-engraftment phase. Similarly, there was lack of uniformity in indication, dosing and duration of maintenance therapy. Divergence was noted between responses from HSCT and ID physicians within centres. This study identifies areas of uniformity and others of great variability in prevention and management strategies for CMV in paediatric HSCT. Data on CMV infection and management in HSCT patients should be routinely collected as part of prospective trials to inform guidelines and improve prevention and treatment of this important complication.

Original languageEnglish
Article numbere13458
Pages (from-to)e13458
JournalPediatric Transplantation
Volume23
Issue number5
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Antiviral Agents/therapeutic use
  • Australia
  • Child
  • Cytomegalovirus Infections/prevention & control
  • Female
  • Ganciclovir/therapeutic use
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • New Zealand
  • Practice Patterns, Physicians'/statistics & numerical data
  • Risk Factors
  • Surveys and Questionnaires

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