Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

A. A. Al-Qarawi; H. A. Abdel-Rahman; B. H. Ali; S. A. El Mougy

doi:10.1016/S0278-6915(02)00080-7

Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

A. A. Al-Qarawi, H. A. Abdel-Rahman, B. H. Ali^*, S. A. El Mougy

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.

Original language	English
Pages (from-to)	1525-1527
Number of pages	3
Journal	Food and Chemical Toxicology
Volume	40
Issue number	10
DOIs	https://doi.org/10.1016/S0278-6915(02)00080-7
Publication status	Published - Oct 2002

Keywords

Adrenal gland
Aldosterone
Liquorice
Pituitary
Rats

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/S0278-6915(02)00080-7

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abstract = "The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.",

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AU - Al-Qarawi, A. A.

AU - Abdel-Rahman, H. A.

AU - Ali, B. H.

AU - El Mougy, S. A.

PY - 2002/10

Y1 - 2002/10

N2 - The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.

AB - The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.

KW - Adrenal gland

KW - Aldosterone

KW - Liquorice

KW - Pituitary

KW - Rats

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Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

Abstract

Keywords

ASJC Scopus subject areas

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