Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats

A. A. Al-Qarawi, H. A. Abdel-Rahman, B. H. Ali*, S. A. El Mougy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


The effect of oral administration of a water freeze-dried extract of Glycyrrhiza glabra (liquorice) has been studied at doses of 100, 250 and 500 mg/kg in rats on the plasma concentration of cortisol, adrenocorticotrophic hormone (ACTH), aldosterone, renin, sodium (Na) and potassium (K). The results indicated that treatment induced dose-dependent and mostly significant decreases in the concentration of cortisol, ACTH, aldosterone and K. There were concomitant dose-dependent increases in the concentrations of renin and Na. The results suggest a strong and dose-dependent suppression of the adrenal-pituitary axis, accompanied by stimulation of renin production from the kidney.

Original languageEnglish
Pages (from-to)1525-1527
Number of pages3
JournalFood and Chemical Toxicology
Issue number10
Publication statusPublished - Oct 2002


  • Adrenal gland
  • Aldosterone
  • Liquorice
  • Pituitary
  • Rats

ASJC Scopus subject areas

  • Food Science
  • Toxicology


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