TY - JOUR
T1 - Langerhans Cell Hyperplasia Mimicking Langerhans Cell Histiocytosis
T2 - A Rare Complication of COVID-19 Vaccination
AU - Qureshi, Asim
AU - Al Khabori, Murtadha
AU - Al Haddabi, Ibrahim Hassan
AU - Qureshi, Hannia
AU - Jawa, Zabah
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/11/9
Y1 - 2023/11/9
N2 - Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation of Langerhans cells, a type of immune cell that is normally present in the skin and various other tissues. LCH can affect people of any age but is most commonly diagnosed in children. We report a case of a patient with LCH who developed ipsilateral axillary lymphadenopathology post-COVID-19 vaccination. Lymph node biopsy showed diffuse Langerhans cell hyperplasia which mimicked LCH. Clinically and radiologically, it looked to be a reactive lymph node. The patient was kept on follow up only and after 1 year of follow up the size of lymph nodes regressed confirming to be reactive in nature rather than neoplastic. To the best of our knowledge, this is the second case of Langerhans cell hyperplasia post-COVID-19 vaccination being reported in the literature.
AB - Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation of Langerhans cells, a type of immune cell that is normally present in the skin and various other tissues. LCH can affect people of any age but is most commonly diagnosed in children. We report a case of a patient with LCH who developed ipsilateral axillary lymphadenopathology post-COVID-19 vaccination. Lymph node biopsy showed diffuse Langerhans cell hyperplasia which mimicked LCH. Clinically and radiologically, it looked to be a reactive lymph node. The patient was kept on follow up only and after 1 year of follow up the size of lymph nodes regressed confirming to be reactive in nature rather than neoplastic. To the best of our knowledge, this is the second case of Langerhans cell hyperplasia post-COVID-19 vaccination being reported in the literature.
KW - COVID 19
KW - hyperplasia
KW - Langerhans cells
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U2 - 10.1177/10668969231206571
DO - 10.1177/10668969231206571
M3 - Article
C2 - 37946499
SN - 1066-8969
SP - 10668969231206571
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
ER -