Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas

Ahmed Ismail Hassan Moad, Mei Lan Tan, Gurjeet Kaur, Mohamed Mabruk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that p15INK4b could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate p15INK4b protein expression in BCCs. Materials and Method: Protein expression of p15INK4b in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of p15INK4b was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and p15INK4b protein expression. Conclusions: Our finding may indicate that p15INK4b protein expression does not play a role in the genesis of BCC.

Original languageEnglish
Pages (from-to)6239-6244
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Issue number12
Publication statusPublished - 2012
Externally publishedYes


  • Basal cell carcinoma
  • Immunohistichemistry
  • P15Ink4B

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research


Dive into the research topics of 'Lack of Increased P15ink4b protein Expression in Basal Cell Carcinomas'. Together they form a unique fingerprint.

Cite this