KMT2A-MLLT3 AML masquerading as JMML may disguise fatal leukemia

Ashraf Abdullah Saad; Ismail Beshlawi; Mathew Zachariah; Yasser Wali

doi:10.5001/omj.2019.99

KMT2A-MLLT3 AML masquerading as JMML may disguise fatal leukemia

Ashraf Abdullah Saad^*, Ismail Beshlawi, Mathew Zachariah, Yasser Wali

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.

Original language	English
Pages (from-to)	553-555
Number of pages	3
Journal	Oman Medical Journal
Volume	34
Issue number	6
DOIs	https://doi.org/10.5001/omj.2019.99
Publication status	Published - Nov 2019

Keywords

Acute Myeloid Leukemia
Histone-Lysine N-Methyltransferase 2A
Juvenile Myelomonocytic Leukemia

ASJC Scopus subject areas

Medicine(all)

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10.5001/omj.2019.99

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title = "KMT2A-MLLT3 AML masquerading as JMML may disguise fatal leukemia",

abstract = "We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.",

keywords = "Acute Myeloid Leukemia, Histone-Lysine N-Methyltransferase 2A, Juvenile Myelomonocytic Leukemia",

author = "Saad, {Ashraf Abdullah} and Ismail Beshlawi and Mathew Zachariah and Yasser Wali",

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AU - Saad, Ashraf Abdullah

AU - Beshlawi, Ismail

AU - Zachariah, Mathew

AU - Wali, Yasser

PY - 2019/11

Y1 - 2019/11

N2 - We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.

AB - We present a mortality case showcasing t(9;11)-positive acute myeloid leukemia/juvenile myelomonocytic leukemia (AML/JMML) overlap to shed light on this lethal molecular subtype of AML. In this case, the flawed assumption that JMML was to blame impeded the prompt undertaking of appropriate treatment for AML in our 14-month-old patient. This article aims to scrutinize the catastrophic sequel of such an overlap in leukemia and refutes the contemporary diagnostic methods.

KW - Acute Myeloid Leukemia

KW - Histone-Lysine N-Methyltransferase 2A

KW - Juvenile Myelomonocytic Leukemia

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KMT2A-MLLT3 AML masquerading as JMML may disguise fatal leukemia

Abstract

Keywords

ASJC Scopus subject areas

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