Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones

Aobha Hickey, Julia Merz, Hamad H. Al Mamari, Alexandra Friedrich, Todd B. Marder, Gerard P. McGlacken

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone-the core structure of many antibiotics.

Original languageEnglish
Pages (from-to)9977-9987
Number of pages11
JournalJournal of Organic Chemistry
Issue number15
Publication statusPublished - Jul 15 2022
Externally publishedYes


  • Boron Compounds/chemistry
  • Catalysis
  • Fluoroquinolones
  • Iridium/chemistry
  • Molecular Structure

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones'. Together they form a unique fingerprint.

Cite this