Invasive pleomorphic lobular carcinoma of the breast: Pathologic, clinical, and therapeutic considerations

Khalid Al-Baimani, Amy Bazzarelli, Mark Clemons, Susan J. Robertson, Christina Addison, Angel Arnaout*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Pleomorphic lobular carcinoma is an uncommon form of breast cancer and a subtype of invasive lobular carcinoma. It has unique histopathologic features that translate to a more aggressive phenotype with an associated poor prognosis. Unlike classical invasive lobular carcinoma, it can lose estrogen and progesterone receptor expression and demonstrate HER-2/neu amplification. It remains to be determined, however, whether the pleomorphic histology independently predicts a worse outcome or whether other known associated negative prognostic factors such as larger tumor size, increased metastatic disease, and associated worse molecular subtypes commonly present in pleomorphic carcinoma account for the poor prognosis. Here we present an updated review of the unique pathologic and clinical features of pleomorphic lobular carcinoma needed to guide management for women with this subtype of cancer.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalClinical Breast Cancer
Issue number6
Publication statusPublished - Dec 2015
Externally publishedYes


  • Breast cancer
  • Diagnosis
  • Histopathology
  • Invasive lobular cancer
  • Management
  • Pathogenesis
  • Pleomorphic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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