Induction of myocardial infarction in experimental animals: A review

Syarifah Aisyah Syed Abd Halim, Norzana Abd Ghafar*, Zakiah Jubri, Srijit Das

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.

Original languageEnglish
JournalJournal of Clinical and Diagnostic Research
Issue number11
Publication statusPublished - Nov 2018


  • Coronary artery
  • Isoprenaline
  • Ligation
  • Myocardial infarction

ASJC Scopus subject areas

  • Clinical Biochemistry


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