Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties

Ines Barkia, Lamya Al-Haj, Azizah Abdul Hamid, Mutaharah Zakaria, Nazamid Saari*, Fahad Zadjali

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.

Original languageEnglish
Pages (from-to)1514-1522
Number of pages9
JournalInternational Journal of Food Science and Technology
Issue number5
Publication statusPublished - May 2019


  • ACE-inhibitory activity
  • antihypertensive activity
  • antioxidant activity
  • marine microalgae
  • protein hydrolysates

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering


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