Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study

Ibrahim Al-Zakwani; Wael Al Mahmeed; Abdullah Shehab; Mohamed Arafah; Ali T. Al-Hinai; Omer Al Tamimi; Mahmoud Al Awadhi; Shorook Al Herz; Faisal Al Anazi; Khalid Al Nemer; Othman Metwally; Akram Alkhadra; Mohammed Fakhry; Hossam Elghetany; Abdel Razak Medani; Afzal Hussein Yusufali; Obaid Al Jassim; Omar Al Hallaq; Fahad Omar Ahmed S. Baslaib; Haitham Amin; Khalid Al-Waili; Khamis Al-Hashmi; Raul D. Santos; Khalid Al-Rasadi

doi:10.1186/s13098-016-0160-6

Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study

Ibrahim Al-Zakwani, Wael Al Mahmeed, Abdullah Shehab, Mohamed Arafah, Ali T. Al-Hinai, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar Ahmed S. Baslaib, Haitham AminKhalid Al-Waili, Khamis Al-Hashmi, Raul D. Santos, Khalid Al-Rasadi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P < 0.001), LDL-C (27 vs. 37 %; P < 0.001), non HDL-C (35 vs. 55 %; P < 0.001) and Apo B (35 vs. 54 %; P < 0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P < 0.001), LDL-C (24 vs. 43 %; P < 0.001), non HDL-C (32 vs. 51 %; P < 0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P < 0.001), LDL-C (19 vs. 27 %; P < 0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

Original language	English
Article number	49
Journal	Diabetology and Metabolic Syndrome
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/s13098-016-0160-6
Publication status	Published - Jul 26 2016

Keywords

Arabian Gulf
Blood pressure
Cardiovascular diseases
HDL cholesterol
LDL cholesterol
Metabolic syndrome
Obesity
Triglycerides

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s13098-016-0160-6

Cite this

Al-Zakwani, I., Al Mahmeed, W., Shehab, A., Arafah, M., Al-Hinai, A. T., Al Tamimi, O., Al Awadhi, M., Al Herz, S., Al Anazi, F., Al Nemer, K., Metwally, O., Alkhadra, A., Fakhry, M., Elghetany, H., Medani, A. R., Yusufali, A. H., Al Jassim, O., Al Hallaq, O., Baslaib, F. O. A. S., ... Al-Rasadi, K. (2016). Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study. Diabetology and Metabolic Syndrome, 8(1), Article 49. https://doi.org/10.1186/s13098-016-0160-6

Al-Zakwani, I, Al Mahmeed, W, Shehab, A, Arafah, M, Al-Hinai, AT, Al Tamimi, O, Al Awadhi, M, Al Herz, S, Al Anazi, F, Al Nemer, K, Metwally, O, Alkhadra, A, Fakhry, M, Elghetany, H, Medani, AR, Yusufali, AH, Al Jassim, O, Al Hallaq, O, Baslaib, FOAS, Amin, H, Al-Waili, K , Al-Hashmi, K, Santos, RD & Al-Rasadi, K 2016, 'Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study', Diabetology and Metabolic Syndrome, vol. 8, no. 1, 49. https://doi.org/10.1186/s13098-016-0160-6

@article{82f391f8d1e944b3bf57b572776d18bd,

title = "Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study",

abstract = "Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P < 0.001), LDL-C (27 vs. 37 %; P < 0.001), non HDL-C (35 vs. 55 %; P < 0.001) and Apo B (35 vs. 54 %; P < 0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P < 0.001), LDL-C (24 vs. 43 %; P < 0.001), non HDL-C (32 vs. 51 %; P < 0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P < 0.001), LDL-C (19 vs. 27 %; P < 0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.",

keywords = "Arabian Gulf, Blood pressure, Cardiovascular diseases, HDL cholesterol, LDL cholesterol, Metabolic syndrome, Obesity, Triglycerides",

author = "Ibrahim Al-Zakwani and {Al Mahmeed}, Wael and Abdullah Shehab and Mohamed Arafah and Al-Hinai, {Ali T.} and {Al Tamimi}, Omer and {Al Awadhi}, Mahmoud and {Al Herz}, Shorook and {Al Anazi}, Faisal and {Al Nemer}, Khalid and Othman Metwally and Akram Alkhadra and Mohammed Fakhry and Hossam Elghetany and Medani, {Abdel Razak} and Yusufali, {Afzal Hussein} and {Al Jassim}, Obaid and {Al Hallaq}, Omar and Baslaib, {Fahad Omar Ahmed S.} and Haitham Amin and Khalid Al-Waili and Khamis Al-Hashmi and Santos, {Raul D.} and Khalid Al-Rasadi",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = jul,

day = "26",

doi = "10.1186/s13098-016-0160-6",

language = "English",

volume = "8",

journal = "Diabetology and Metabolic Syndrome",

issn = "1758-5996",

publisher = "BioMed Central",

number = "1",

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TY - JOUR

T1 - Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf

T2 - Findings from the CEPHEUS study

AU - Al-Zakwani, Ibrahim

AU - Al Mahmeed, Wael

AU - Shehab, Abdullah

AU - Arafah, Mohamed

AU - Al-Hinai, Ali T.

AU - Al Tamimi, Omer

AU - Al Awadhi, Mahmoud

AU - Al Herz, Shorook

AU - Al Anazi, Faisal

AU - Al Nemer, Khalid

AU - Metwally, Othman

AU - Alkhadra, Akram

AU - Fakhry, Mohammed

AU - Elghetany, Hossam

AU - Medani, Abdel Razak

AU - Yusufali, Afzal Hussein

AU - Al Jassim, Obaid

AU - Al Hallaq, Omar

AU - Baslaib, Fahad Omar Ahmed S.

AU - Amin, Haitham

AU - Al-Waili, Khalid

AU - Al-Hashmi, Khamis

AU - Santos, Raul D.

AU - Al-Rasadi, Khalid

PY - 2016/7/26

Y1 - 2016/7/26

N2 - Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P < 0.001), LDL-C (27 vs. 37 %; P < 0.001), non HDL-C (35 vs. 55 %; P < 0.001) and Apo B (35 vs. 54 %; P < 0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P < 0.001), LDL-C (24 vs. 43 %; P < 0.001), non HDL-C (32 vs. 51 %; P < 0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P < 0.001), LDL-C (19 vs. 27 %; P < 0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

AB - Background: The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf. Methods: The centralized pan-middle east survey on the undertreatment of hypercholesterolemia (CEPHEUS) included 4171 high and very high atherosclerotic cardiovascular disease (ASCVD) risk patients from six Arabian Gulf countries. Analyses were performed using univariate statistics. Results: The overall mean age was 57 ± 11 years, 41 % were females and 71 % had MetS. MetS patients were less likely to attain their HDL-C (34 vs. 79 %; P < 0.001), LDL-C (27 vs. 37 %; P < 0.001), non HDL-C (35 vs. 55 %; P < 0.001) and Apo B (35 vs. 54 %; P < 0.001) compared to those without MetS. Within the MetS cohort, those with very high ASCVD risk were less likely to attain their lipid targets compared to those with high ASCVD risk [HDL-C (32 vs. 41 %; P < 0.001), LDL-C (24 vs. 43 %; P < 0.001), non HDL-C (32 vs. 51 %; P < 0.001) and Apo B (33 vs. 40 %; P = 0.001)]. In those with MetS and very high ASCVD risk status, females were less likely to attain their HDL-C (27 vs. 36 %; P < 0.001), LDL-C (19 vs. 27 %; P < 0.001) and Apo B (30 vs. 35 %; P = 0.009) compared to males. Conclusions: MetS was associated with low lipid therapeutic targets. Women and those with very high ASCVD risk were also less likely to attain their lipid targets in the Arabian Gulf.

KW - Arabian Gulf

KW - Blood pressure

KW - Cardiovascular diseases

KW - HDL cholesterol

KW - LDL cholesterol

KW - Metabolic syndrome

KW - Obesity

KW - Triglycerides

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U2 - 10.1186/s13098-016-0160-6

DO - 10.1186/s13098-016-0160-6

M3 - Article

C2 - 27468314

AN - SCOPUS:84979561670

SN - 1758-5996

VL - 8

JO - Diabetology and Metabolic Syndrome

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M1 - 49

ER -

Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: Findings from the CEPHEUS study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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