TY - JOUR
T1 - Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum
AU - Abdala Díaz, Roberto T.
AU - Casas Arrojo, V.
AU - Arrojo Agudo, M. A.
AU - Cárdenas, C.
AU - Dobretsov, S.
AU - Figueroa, F. L.
N1 - Funding Information:
Acknowledgements We want to express our gratitude to the Photobiology and Biotechnology of Aquatic Organisms (FYBOA) research group (RNM-295) for their financial support. We also want to thank Dr. Luis Alemany and Dr. María de los Ángeles Vargas (Chemical Engineering Department, UMA) for their technical assistance in the FT-IR analysis and D. Augusto Martínez García, Technical Manager of the Chemical Analysis and Material Characterization Area: Elemental and Thermal Analysis Unit of the SCAI (Central Research Support Service) of the University of Malaga, for the technical assistance in the elementary analysis of the samples.
Funding Information:
We want to express our gratitude to the Photobiology and Biotechnology of Aquatic Organisms (FYBOA) research group (RNM-295) for their financial support. We also want to thank Dr. Luis Alemany and Dr. Mar?a de los ?ngeles Vargas (Chemical Engineering Department, UMA) for their technical assistance in the FT-IR analysis and D. Augusto Mart?nez Garc?a, Technical Manager of the Chemical Analysis and Material Characterization Area: Elemental and Thermal Analysis Unit of the SCAI (Central Research Support Service) of the University of Malaga, for the technical assistance in the elementary analysis of the samples.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast of Tarifa (Cadiz, Spain). The proliferation of murine cell line RAW 264 decreased with increasing concentration of polysaccharides of the three algal species. The highest both antioxidant (25.69 μmol TE g−1 DW) and immunomodulatory activities were observed in the sulfated polysaccharides of L. ochroleuca compared to that of P. umbilicalis and G. corneum. Sulfated polysaccharides of L. ochroleuca presented high potential anticancer activity in cell lines of human colon cancer HTC-116 (IC50 = 0.44 mg mL−1), human malignant melanoma G-361 (IC50 = 5.42 mg mL−1), breast adenocarcinoma human MCF-7 (IC50 = 8.32 mg mL−1), and human leukemia U-937 (IC50 = 3.72 mg mL−1). It is concluded that metabolites of L. ochroleuca can offer significant advantages for the pharmaceutical industry, particularly when macrophage activation is required.
AB - Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast of Tarifa (Cadiz, Spain). The proliferation of murine cell line RAW 264 decreased with increasing concentration of polysaccharides of the three algal species. The highest both antioxidant (25.69 μmol TE g−1 DW) and immunomodulatory activities were observed in the sulfated polysaccharides of L. ochroleuca compared to that of P. umbilicalis and G. corneum. Sulfated polysaccharides of L. ochroleuca presented high potential anticancer activity in cell lines of human colon cancer HTC-116 (IC50 = 0.44 mg mL−1), human malignant melanoma G-361 (IC50 = 5.42 mg mL−1), breast adenocarcinoma human MCF-7 (IC50 = 8.32 mg mL−1), and human leukemia U-937 (IC50 = 3.72 mg mL−1). It is concluded that metabolites of L. ochroleuca can offer significant advantages for the pharmaceutical industry, particularly when macrophage activation is required.
KW - Antioxidant activity
KW - Immunomodulator
KW - Macroalgae
KW - Seaweeds
KW - Sulfated polysaccharides
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UR - http://www.scopus.com/inward/citedby.url?scp=85068351170&partnerID=8YFLogxK
U2 - 10.1007/s10126-019-09905-x
DO - 10.1007/s10126-019-09905-x
M3 - Article
C2 - 31250232
AN - SCOPUS:85068351170
SN - 1436-2228
VL - 21
SP - 577
EP - 587
JO - Marine Biotechnology
JF - Marine Biotechnology
IS - 4
ER -