TY - JOUR
T1 - Idiopathic dilated cardiomyopathy in an Omani population of the Arabian Peninsula
T2 - Prevalence, clinical profile and natural history
AU - Agarwal, A. K.
AU - Venugopalan, P.
AU - Meharali, A. K.
AU - De Debono, D.
PY - 2000/9/15
Y1 - 2000/9/15
N2 - We have analysed prospectively the prevalence and clinical profile of idiopathic dilated cardiomyopathy (IDC) in a circumscribed native population of the Sultanate of Oman over 3 years (1992-1994). Identified patients were followed up for a period ranging from 1 to 8 years (median 4 years) and the variables related to outcome determined. IDC was diagnosed in 97 patients, giving a prevalence of 43.2/100,000 population during the study period. 84.5% of patients were aged over 35 years and males outnumbered females (M/F = 1.4:1). Factors related to poor outcome were an initial left ventricular ejection fraction ≤30% (P = 0.01), severe symptoms, i.e. NYHA functional class III or IV at presentation (P = 0.04), and significant ventricular tachycardia during follow up (P = 0.02). However, multivariate regression analysis yielded only low LVEF as the predictor of poor outcome (P = 0.01). When analysed from age of onset of symptoms, survival figures were 94% at 1 year (95% CI 88 to 99%), 76% at 5 years (95% CI 67 to 86%) and 68% at 8 years (95% CI 54 to 82%). Mean survival was 6.5 years (95% CI 6 to 7 years). Patients were still at risk of fatal ventricular arrhythmia even when haemodynamically stable and had left ventricular ejection fraction >30%. (C) 2000 Elsevier Science Ireland Ltd.
AB - We have analysed prospectively the prevalence and clinical profile of idiopathic dilated cardiomyopathy (IDC) in a circumscribed native population of the Sultanate of Oman over 3 years (1992-1994). Identified patients were followed up for a period ranging from 1 to 8 years (median 4 years) and the variables related to outcome determined. IDC was diagnosed in 97 patients, giving a prevalence of 43.2/100,000 population during the study period. 84.5% of patients were aged over 35 years and males outnumbered females (M/F = 1.4:1). Factors related to poor outcome were an initial left ventricular ejection fraction ≤30% (P = 0.01), severe symptoms, i.e. NYHA functional class III or IV at presentation (P = 0.04), and significant ventricular tachycardia during follow up (P = 0.02). However, multivariate regression analysis yielded only low LVEF as the predictor of poor outcome (P = 0.01). When analysed from age of onset of symptoms, survival figures were 94% at 1 year (95% CI 88 to 99%), 76% at 5 years (95% CI 67 to 86%) and 68% at 8 years (95% CI 54 to 82%). Mean survival was 6.5 years (95% CI 6 to 7 years). Patients were still at risk of fatal ventricular arrhythmia even when haemodynamically stable and had left ventricular ejection fraction >30%. (C) 2000 Elsevier Science Ireland Ltd.
KW - Epidemiology
KW - Idiopathic dilated cardiomyopathy
KW - Middle East
KW - Outcome variables
KW - Survival
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U2 - 10.1016/S0167-5273(00)00315-6
DO - 10.1016/S0167-5273(00)00315-6
M3 - Article
C2 - 11077126
AN - SCOPUS:0034664894
SN - 0167-5273
VL - 75
SP - 147
EP - 158
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2-3
ER -