TY - JOUR
T1 - Global Perspectives on the Hepatitis B Vaccination
T2 - Challenges, Achievements, and the Road to Elimination by 2030
AU - Al-Busafi, Said A
AU - Alwassief, Ahmed
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/9
Y1 - 2024/9
N2 - Annually, more than 1.5 million preventable new hepatitis B (HBV) infections continue to occur, with an estimated global burden of 296 million individuals living with chronic hepatitis B infection. This substantial health challenge results in over 820,000 annual deaths being attributed to complications such as liver cirrhosis and hepatocellular carcinoma (HCC). The HBV vaccination remains the cornerstone of public health policy to prevent chronic hepatitis B and its related complications. It serves as a crucial element in the global effort to eliminate HBV, as established by the World Health Organization (WHO), with an ambitious 90% vaccination target by 2030. However, reports on global birth dose coverage reveal substantial variability, with an overall coverage rate of only 46%. This comprehensive review thoroughly examines global trends in HBV vaccination coverage, investigating the profound impact of vaccination on HBV prevalence and its consequences across diverse populations, including both high-risk and general demographics. Additionally, the review addresses the essential formidable challenges and facilitating factors for achieving WHO’s HBV vaccination coverage objectives and elimination strategies in the coming decade and beyond.
AB - Annually, more than 1.5 million preventable new hepatitis B (HBV) infections continue to occur, with an estimated global burden of 296 million individuals living with chronic hepatitis B infection. This substantial health challenge results in over 820,000 annual deaths being attributed to complications such as liver cirrhosis and hepatocellular carcinoma (HCC). The HBV vaccination remains the cornerstone of public health policy to prevent chronic hepatitis B and its related complications. It serves as a crucial element in the global effort to eliminate HBV, as established by the World Health Organization (WHO), with an ambitious 90% vaccination target by 2030. However, reports on global birth dose coverage reveal substantial variability, with an overall coverage rate of only 46%. This comprehensive review thoroughly examines global trends in HBV vaccination coverage, investigating the profound impact of vaccination on HBV prevalence and its consequences across diverse populations, including both high-risk and general demographics. Additionally, the review addresses the essential formidable challenges and facilitating factors for achieving WHO’s HBV vaccination coverage objectives and elimination strategies in the coming decade and beyond.
KW - barriers
KW - elimination
KW - hepatitis B
KW - liver disease
KW - vaccination
KW - WHO
UR - http://www.scopus.com/inward/record.url?scp=85188881863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85188881863&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/aee343b0-a00c-38f2-bfce-54acf4483ac6/
U2 - 10.3390/vaccines12030288
DO - 10.3390/vaccines12030288
M3 - Article
C2 - 38543922
SN - 2076-393X
VL - 12
JO - Vaccines
JF - Vaccines
IS - 3
M1 - 288
ER -