TY - JOUR
T1 - Genome-wide linkage analysis of hemodynamic parameters under mental and physical stress in extended Omani Arab pedigrees
T2 - The Oman family study
AU - Hassan, Mohammed O.
AU - Jaju, Deepali
AU - Voruganti, V. Saroja
AU - Bayoumi, Riad A.
AU - Albarwani, Sulayma
AU - Al-Yahyaee, Saeed
AU - Aslani, Afshin
AU - Snieder, Harold
AU - Lopez-Alvarenga, Juan C.
AU - Al-Anqoudi, Zahir M.
AU - Alizadeh, Behrooz Z.
AU - Comuzzie, Anthony G.
N1 - Funding Information:
This work was supported by His Majesty Sultan Qaboos Strategic Research Trust Fund (Grant SR/MED/PHYS/04/ 01). We thank the Ministry of Health for supporting the work. We also thank the people of the Taimsa, Birkat Al-Moz, Radat Al-Busaidi, Karsha, and Farq villages for their continuous encouragement and participation.
PY - 2011/6
Y1 - 2011/6
N2 - Background: We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests. Methods: The Oman Family Study subjects (N = 1277) were recruited from five extended families of ∼10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (Δ), using variance components decomposition-based methods implemented in SOLAR. Results: Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For ΔWCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For ΔCPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.
AB - Background: We performed a genome-wide scan in a homogeneous Arab population to identify genomic regions linked to blood pressure (BP) and its intermediate phenotypes during mental and physical stress tests. Methods: The Oman Family Study subjects (N = 1277) were recruited from five extended families of ∼10 generations. Hemodynamic phenotypes were computed from beat-to-beat BP, electrocardiography and impedance cardiography. Multi-point linkage was performed for resting, mental (word conflict test, WCT) and cold pressor (CPT) stress and their reactivity scores (Δ), using variance components decomposition-based methods implemented in SOLAR. Results: Genome-wide scans for BP phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT-linked cardiac output (LOD = 3.1) and systolic BP (LOD = 3.5). Evidence for suggestive linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), DBP (LOD = 2.4) and left ventricular ejection time (LVET), respectively. For ΔWCT, suggestive QTLs were detected for CO on chr11 (LOD = 2.5), LVET on chr3 (LOD = 2.0) and EDI on chr9 (LOD = 2.1). For CPT, suggestive QTLs for HR and LVET shared the same region on chr22 (LOD 2.3 and 2.8, respectively) and on chr9 (LOD = 2.3) for SBP, chr7 (LOD = 2.4) for SV and chr19 (LOD = 2.6) for CO. For ΔCPT, CO and TPR top signals were detected on chr15 and 10 (LOD; 2.40, 2.08) respectively. Conclusion: Mental stress revealed the largest number of significant and suggestive loci for normal BP reported to date. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis of essential hypertension.
KW - Arab pedigrees
KW - Genome-wide
KW - Haemodynamics
KW - Linkage
KW - Stress
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U2 - 10.1375/twin.14.3.257
DO - 10.1375/twin.14.3.257
M3 - Article
C2 - 21623656
AN - SCOPUS:79957634324
SN - 1832-4274
VL - 14
SP - 257
EP - 267
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 3
ER -