Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid: A case series

Mohammed Al Huneini; Fauzia Wasim; Khalil Al Farsi; Murtadha Al-Khabori; Salam A. Al Kindi

doi:10.5001/omj.2013.56

Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid: A case series

Mohammed Al Huneini, Fauzia Wasim, Khalil Al Farsi, Murtadha Al-Khabori, Salam A. Al Kindi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.

Original language	English
Pages (from-to)	207-209
Number of pages	3
Journal	Oman Medical Journal
Volume	28
Issue number	3
DOIs	https://doi.org/10.5001/omj.2013.56
Publication status	Published - 2013

Keywords

ATRA
Acute promyelocytic leukaemia
All-trans retinoic acid
Fever
Scrotal ulcers

ASJC Scopus subject areas

Medicine(all)

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10.5001/omj.2013.56

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abstract = "We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.",

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AU - Wasim, Fauzia

AU - Al Farsi, Khalil

AU - Al-Khabori, Murtadha

AU - Al Kindi, Salam A.

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AB - We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.

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Genital ulcer development in patients with acute promyelocytic leukaemia treated with all-trans retinoic acid: A case series

Abstract

Keywords

ASJC Scopus subject areas

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