Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis

Patrick Watts, Shahab H. Agha, Maha Mameesh, Phillip Conor, Anuradha Ganesh*, Abdullah Al-Mujaini, Hugh Jewsbury, Anil Pathare, Abdulhakim Al-Rawas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Ligneous conjunctivitis is a rare form of chronic recurrent membranous conjunctivitis with reduced plasminogen activity. It is characterized by the formation of characteristic firm (“woody”) membranes on the tarsal conjunctiva. Similar lesions may occur on other mucous membranes. When treated with local excision, ligneous conjunctivitis is invariably associated with recurrences. Various therapeutic modalities, including topical heparin, cyclosporine, fresh frozen plasma (FFP), plasminogen, and amniotic membrane transplantation have been reported to reduce postoperative recurrences. We present 2 cases of recurrent ligneous conjunctivitis in children successfully managed with surgical excision under cover of FFP transfusion, amniotic membrane grafting, and combined with concomitant postoperative administration of topical heparin, steroids.(Figure presented.)

Original languageEnglish
Pages (from-to)42-45.e1
JournalJournal of AAPOS
Issue number1
Publication statusPublished - Feb 2019

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology


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