Factor V Leiden gene mutation in young Indian patients with myocardial infarction

Dipika Mohanty*, Shrimati Shetty, C. R. Anil, Anil Pathare, Kanjaksha Ghosh, M. E. Yeolekar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Myocardial infarction (MI) in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic coronary risk factors. Factor V Leiden gene mutation, the underlying cause of activated protein C resistance, is the commonest cause for venous thrombosis. It is still not clear whether there is any relationship between this genetic defect and arterial thrombosis. We have studied the prevalence of factor V Leiden mutation in a selective group of young patients with myocardial infarction (MI), aged <45 years, to assess, whether it increases the risk of MI in this group of patients, in whom not only MI is a rare event, but also most of the well known risk factors for MI such as hypercholesterolemia and hypertension are also uncommon. Two cases (5%) were found to be carriers of factor V Leiden mutation, who were also found to be chronic smokers. This preliminary study is an attempt to study a genetic risk factor for thrombosis, i.e. Factor V Leiden mutation to observe whether it is responsible alone or interacting with other risk factors increases the risk for mycordial infarction.

Original languageEnglish
Pages (from-to)1078-1080
Number of pages3
JournalCurrent Science
Issue number12
Publication statusPublished - Jun 25 1998
Externally publishedYes

ASJC Scopus subject areas

  • General


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