TY - JOUR
T1 - Exosomes in Alzheimer’s Disease
T2 - Potential Role as Pathological Mediators, Biomarkers and Therapeutic Targets
AU - Lakshmi, Sreeja
AU - Essa, Musthafa Mohamed
AU - Hartman, Richard E.
AU - Guillemin, Gilles J.
AU - Sivan, Sureshkumar
AU - Elumalai, Preetham
N1 - Funding Information:
The authors deeply acknowledge Department of Health Research, New Delhi, for the encouragement and financial assistance (No. R.12013/04/2017-HR) towards HRD fellowship- Women Scientist with break in career to SL.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of Alzheimer’s disease (AD), the most prevailing multifactorial neurodegenerative disorder. A potential novel therapeutic role of exosomes in AD intervention is suggested by their ability to increase Aβ clearance. This review aims to highlight the important pathological mechanisms as well as therapeutic strategies involving exosomes towards AD prevention.
AB - The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of Alzheimer’s disease (AD), the most prevailing multifactorial neurodegenerative disorder. A potential novel therapeutic role of exosomes in AD intervention is suggested by their ability to increase Aβ clearance. This review aims to highlight the important pathological mechanisms as well as therapeutic strategies involving exosomes towards AD prevention.
KW - Alzheimer´s disease
KW - Biomarkers
KW - Exosomes
KW - Tau protein
KW - β-amyloid
UR - http://www.scopus.com/inward/record.url?scp=85089867069&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089867069&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b430e23b-2193-305f-9558-1f07508f474e/
U2 - 10.1007/s11064-020-03111-1
DO - 10.1007/s11064-020-03111-1
M3 - Review article
C2 - 32840760
AN - SCOPUS:85089867069
SN - 0364-3190
VL - 45
SP - 2553
EP - 2559
JO - Neurochemical Research
JF - Neurochemical Research
IS - 11
ER -