Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer

Shika Hanif Malgundkar, Yahya Tamimi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.

Original languageEnglish
Article number157
JournalFuture Science OA
Issue number1
Publication statusPublished - Jan 1 2023
Externally publishedYes


  • biomarkers
  • cell-free messengers
  • exosomes
  • molecular cargo
  • ovarian cancer

ASJC Scopus subject areas

  • Biotechnology

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