Abstract
OBJECTIVE: The present study was taken up to evaluate the combination of two drugs in the management of behavioral disorders such as locomotor activity, muscle relaxation, analgesic, and anxiolytic activity.
MATERIALS AND METHODS: In the methodology, Wistar rats weighing (150-180 g) were divided into six groups of 6 each (n=6). All the animals (groups II to VI) were subjected to stress and analyzed for anxiolytic activity using an elevated plus maze. The animals were treated for 28 days with poppy seed oil in lower and higher doses (1,000 and 2,000 mg/kg), tramadol in lower and higher doses (1.5 and 3 mg/kg) as individual groups, and one group with a combination of both drugs in lower doses.
RESULTS: The results depicted showed that the combined treatment had significantly (**p <0.001) improvised behavior deficits, extemporized, and diminished anxiety-like attitude in rats, and showed the analgesic property in a significant manner. The pro-inflammatory cytokines TNF-α and IL-1β were evaluated in the serum and were observed to be lessened the values of both in a significant manner with the co-administration of both the test drugs. The dopamine concentrations were also determined in the serum, which disclosed a decline (**p <0.001) significantly.
CONCLUSIONS: It was concluded from the results that a combined effect of drugs might be beneficial in the management of behavioral disorders and pain management.
Original language | English |
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Pages (from-to) | 2077-2090 |
Number of pages | 14 |
Journal | European Review for Medical and Pharmacological Sciences |
Volume | 27 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2023 |
Keywords
- Actophotometer
- Analgesic
- Anxiety
- Cytokines
- Dopamine
- Elevated Plus Maze
- Poppy seed oil
- Rota rod
- Anti-Anxiety Agents/pharmacology
- Rats, Wistar
- Rats
- Motor Activity
- Anxiety/drug therapy
- Behavior, Animal
- Papaver
- Tramadol/pharmacology
- Animals
- Plant Oils/pharmacology
ASJC Scopus subject areas
- Pharmacology (medical)