Diagnosis of beta-thalassaemia carriers in the Sultanate of Oman

Shahina Daar*, David Gravell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: Haemoglobinopathies are a major cause of morbidity in the Sultanate of Oman and premarital screening is being encouraged in order to reduce the number of affected births. The identification of β-thalassaemia carrier status is an essential prerequisite of any screening programme. However, the level of Haemoglobin (Hb) A2, which is used to detect β-thalassaemia carriers, can be affected by other factors including iron deficiency, concurrent a thalassaemia and the type of DNA mutation present. Objectives: The following study was undertaken to ascertain if the Hb A2 level is an appropriate tool for the identification of β-thalassaemia carriers in the Omani population. Method: Hb A2 was measured by high performance liquid chromatography (HPLC) in 160 obligate carriers of β-thalassaemia. 158 subjects had Hb A2 levels above 3.5% indicating β-thalassaemia trait. Two subjects had slightly lower levels and were found to be iron deficient. After therapy both these subjects' Hb A2 levels increased to above 3.5%. Conclusion: In the absence of iron deficiency, Hb A2 is an accurate marker for the presence of β-thalassaemia trait in the Sultanate of Oman.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalSultan Qaboos University Medical Journal
Issue number1
Publication statusPublished - Jun 2006


  • Hb A
  • Sultanate of Oman
  • β-thalassaemia trait

ASJC Scopus subject areas

  • General Medicine


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