Determination of ibuprofen in pharmaceutical formulations using time-resolved terbium-sensitized luminescence

Salma M.Z. Al-Kindy*, Fakhr Eldin O. Suliman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were <1.4%, indicating excellent reproducibility. The proposed method was successfully applied for the assays of IB in pharmaceutical formulations with average recoveries of 100.3-102.5%.

Original languageEnglish
Pages (from-to)294-301
Number of pages8
Issue number4
Publication statusPublished - 2007
Externally publishedYes


  • Drug formulations
  • Ibuprofen
  • Sensitized luminescence
  • Terbium

ASJC Scopus subject areas

  • Biophysics
  • Chemistry (miscellaneous)


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