TY - JOUR
T1 - Challenges in managing chronic kidney disease with simultaneous renal transplant immunosuppressant induced buccal squamous cell carcinoma and gastric Burkitt's like lymphoma
T2 - A case report
AU - Tajammul, Syeda Sara
AU - Maheshwari, Shruti
AU - Munir, Javeria
AU - Al-Farsi, Khalil
AU - Allawati, Ali
AU - Hashami, Zamzam Al
AU - Mula-Hussain, Layth
N1 - Publisher Copyright:
© 2024
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Immunodeficiency is associated with higher cancer incidence, especially in transplanted patients; however, it is unknown whether there is a link between immunodeficiency and the development of multiple primary malignancies. Immunosuppressive drugs may either indirectly potentiate the effect of carcinogens or directly damage the DNA. Skin cancers are the most common malignancies diagnosed in renal transplant recipients. Management of immunosuppression in recipients of transplants who are living with cancer is complex and challenging. A concerted approach between transplant professionals, oncologists, and allied health professionals is therefore needed to ensure optimal care for transplant recipients who are developing immunodeficiency-induced malignancies. Here, we report a challenging case that presented with two simultaneous malignancies (buccal squamous cell carcinoma and gastric Burkitt's-like lymphoma) after nine years of being on immunosuppressants after the kidney transplant. The patient tolerated his cancer treatments with some grade II-III toxicities and is currently a two-year disease-free survivor. Focusing on the curative intent approaches for the two cancers with the adjustment of the immunosuppressant medications, besides the complications associated with these radical treatments, is worthy of being presented to the transplant and oncology teams globally.
AB - Immunodeficiency is associated with higher cancer incidence, especially in transplanted patients; however, it is unknown whether there is a link between immunodeficiency and the development of multiple primary malignancies. Immunosuppressive drugs may either indirectly potentiate the effect of carcinogens or directly damage the DNA. Skin cancers are the most common malignancies diagnosed in renal transplant recipients. Management of immunosuppression in recipients of transplants who are living with cancer is complex and challenging. A concerted approach between transplant professionals, oncologists, and allied health professionals is therefore needed to ensure optimal care for transplant recipients who are developing immunodeficiency-induced malignancies. Here, we report a challenging case that presented with two simultaneous malignancies (buccal squamous cell carcinoma and gastric Burkitt's-like lymphoma) after nine years of being on immunosuppressants after the kidney transplant. The patient tolerated his cancer treatments with some grade II-III toxicities and is currently a two-year disease-free survivor. Focusing on the curative intent approaches for the two cancers with the adjustment of the immunosuppressant medications, besides the complications associated with these radical treatments, is worthy of being presented to the transplant and oncology teams globally.
KW - Buccal cancer
KW - Gastric Burkitt-like lymphoma
KW - Immunodeficiency
KW - Multiple cancer primaries, Immunosuppressant-induced malignancies
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UR - https://www.mendeley.com/catalogue/0f8b566d-39c6-36a6-a701-c5205f4f5baf/
U2 - 10.1016/j.cpccr.2024.100288
DO - 10.1016/j.cpccr.2024.100288
M3 - Article
AN - SCOPUS:85189670548
SN - 2666-6219
VL - 14
JO - Current Problems in Cancer: Case Reports
JF - Current Problems in Cancer: Case Reports
M1 - 100288
ER -