Catalyst-free microwave-assisted amination of 2-chloro-5-nitrobenzoic acid

Younis Baqi, Christa E. Müller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


(Chemical Equation Presented) The synthesis of N-substituted 5-nitroanthranilic acid derivatives 3a-w was achieved by a new, mild, microwave-assisted, regioselective amination reaction of 5-nitro-2-chlorobenzoic acid (1a) with a diverse range of aliphatic and aromatic amines 2a-w without added solvent or catalyst. Up to >99% isolated yield was obtained within 5-30 min at 80-120°C. The reaction, which is suitable for upscaling, yielded new compounds that are of considerable interest as useful building blocks and as potential drugs.

Original languageEnglish
Pages (from-to)5908-5911
Number of pages4
JournalJournal of Organic Chemistry
Issue number15
Publication statusPublished - Jul 20 2007
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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