Cardio-protective effect of regular transfusion in children with non-transfusion dependent thalassemia (NTDT): A cohort study

Khalfan Al Senaidi, Surekha Maveda, Niranjan Joshi, Hanan Nazir, Mohamed Elshinawy, Shoaib Al Zadjali, Abdulhakim Al Rawas, Islam Elghamry, Yasser Wali, Doaa Khater

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND AIM OF THE WORK: Cardiac complications occur in patients with non-transfusion dependent thalassemia (NTDT). The study aimed to evaluate transfusion effect on systolic and diastolic cardiac function in young NTDT patients. Methods: Study design: Cohort study. Seventeen regularly-transfused patients with NTDT (12.5±5.3 years; group 1) and 15 none/minimally transfused patients (13.2±4.8 years; group 2) were followed up for 5 years and compared as regards their clinical parameters, echocardiographic and Tissue-Doppler-Imaging.

RESULTS: Group 2 patients had significantly higher peak late-diastolic velocity of the left-ventricular-inflow Doppler (Am). Mitral-valve A-wave duration/pulmonary-veins, A-wave duration-ratio and pulmonary-vein S/D velocities-ratio were larger in group 2 as well (p = < 0.01). The diameters of right and left outflow-tract were larger with a higher cardiac-index in patients of group 2. Systolic-function was similar in the 2 studied groups.

CONCLUSION: Diastolic function assessment revealed indicators of an abnormal relaxation of left-ventricle in non-transfused patients, which suggests a diastolic dysfunction. An increase in the diameter of the outflow-tract is likely attributed to high cardiac-output status in non-transfused NTDT patients as they have a higher cardiac index. Early start of regular transfusion for NTDT patients might prevent serious long-term cardiac complications.

Original languageEnglish
Article numbere2022022
Pages (from-to)e2022022
JournalActa Biomedica
Issue number2
Publication statusPublished - May 11 2022


  • Non-transfusion dependent thalassemia (NTDT)
  • echocardiography
  • regular blood transfusion
  • Echocardiography
  • Diastole
  • Ventricular Function, Left
  • Humans
  • Echocardiography, Doppler
  • Child
  • Thalassemia/complications
  • Cohort Studies

ASJC Scopus subject areas

  • Medicine(all)


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