Cardiac involvement in Wilson's disease - An electrocardiographic observation

S. Meenakshi-Sundaram*, S. Sinha, M. Rao, L. K. Prashanth, G. R. Arunodaya, S. Rao, H. S. Swamy, A. B. Taly

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Background: Wilson's disease is known for its protean manifestations; however electrocardiographic abnormalities have not received much attention. Aim: To evaluate the various electrocardiographic (ECG) changes in patients with Wilson's disease. Method: The resting ECGs of 50 patients with Wilson's disease were systematically analyzed independently by three observers after excluding other causes that could induce ECG abnormalities. Result: Fifteen patients had at least one abnormality in the ECG. Sinus tachycardia was seen in eight and sinus bradycardia in six. Other abnormalities included: bifid P wave (1), ST elevation (2), ST depression (2), T inversion (4), ventricular premature contraction - VPC (1) and prominent U waves (1). QRS axis, PR interval, QRS complex, R/S amplitude ratio and QT interval were normal in all. Ventricular premature beats were not recorded in any. None had features of ventricular hypertrophy. There was no statistically significant difference in ECG abnormalities with reference to age, gender, duration of illness or treatment, serum copper or ceruloplasmin, and severity of neurological impairment. Conclusion: ECG abnormalities are not uncommon in Wilson's disease and are presumably related to an underlying cardiomyopathy due to deposition of copper in heart.

Original languageEnglish
Pages (from-to)294-296
Number of pages3
JournalJournal of Association of Physicians of India
Issue numberAPR
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • General Medicine


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