Breast pseudoangiomatous stromal hyperplasia challenges

Adil Aljarrah*, Kamran Malik, Sawhney Sukhpal, Ameera Al-Adi, Huda Al-Moqbali, Marwa Al-Riyami

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Pseudoangiomatous stromal hyperplasia (PASH) is a rare proliferative breast disease. It is characterized by fibrosis of the mammary stroma surrounding breast ducts and lobules with formation of anatomizing capillary-like spaces lined by myofibroblastic cells. Commonly, patients present with a palpable breast mass or continuous breast enlargement. We report a case of a 25 year old lady who presented with painless unilateral swelling of her right breast. Ultrasonography showed heterogeneous, hypoechoic benign appearing breast tissue. Histopathology revealed dense collagenous stroma separated by slit like spaces that were lined by bland spindle cells showing no cytological atypia. With immunohistochemistry, these cells were positive for CD-34 and SMA and negative for the endothelial marker CD-31. Some of these cells were also positive for ER and PR.

Original languageEnglish
Pages (from-to)965-967
Number of pages3
JournalPakistan Journal of Medical Sciences
Issue number5
Publication statusPublished - Oct 2012


  • Benign breast
  • Fibroadenoma
  • PASH

ASJC Scopus subject areas

  • General Medicine


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