Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Edwin A. Mitchell*, Tadd Clayton, Luis García-Marcos, Neil Pearce, Sunia Foliaki, Gary Wong, N. Aït-Khaled, H. R. Anderson, M. I. Asher, R. Beasley, B. Björkstén, B. Brunekreef, J. Crane, P. Ellwood, C. Flohr, F. Forastiere, U. Keil, C. K.W. Lai, J. Mallol, S. MontefortJ. Odhiambo, C. F. Robertson, A. W. Stewart, D. Strachan, E. von Mutius, S. K. Weiland, G. Weinmayr, H. Williams, E. Ellwood, L. de Freitas Souza, D. Rennie, P. Aguilar, L. Amarales, G. Aristizábal, A. M. Cepeda, M. A. Riikjärv, G. Zsigmond, S. N. Mantri, A. V. Pherwani, S. Rego, S. Salvi, S. K. Sharma, T. U. Sukumaran, P. S. Suresh Babu, C. B. Kartasasmita, M. R. Masjedi, A. Steriu, H. Odajima, C. Imanalieva, J. Kudzyte, B. S. Quah, K. H. Teh, M. Baeza-Bacab, M. Barragán-Meijueiro, B. E. Del-Río-Navarro, R. García-Almaráz, S. N. González-Díaz, F. J. Linares-Zapién, J. V. Merida-Palacio, R. MacKay, C. Moyes, P. Pattemore, A. Brêborowicz, G. Lis, R. Câmara, J. M. Lopes dos Santos, C. Nunes, J. E. Rosado Pinto, D. Y.T. Goh, H. B. Lee, R. M. Busquets, I. Carvajal-Urueña, G. García-Hernández, C. González Diáaz, A. Ĺopez-Silvarrey Varela, M. M. Morales-Suárez-Varela, O. Al-Rawas, S. Mohammad, Y. Mohammad, J. L. Huang, C. C. Kao, M. Trakultivakorn, P. Vichyanond, M. C. Lapides, Dirceu Solé, Malcolm Sears, Vivianna Aguirre, Jayant Shah, Karnen Baratawidjaja, Sankei Nishima, Jessie de Bruyne, Bee Wah Lee, Dolores Holgado

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalPediatric Allergy and Immunology
Issue number3
Publication statusPublished - May 1 2014
Externally publishedYes


  • Asthma
  • Eczema
  • Low birthweight
  • Rhinoconjunctivitis
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology


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