Augmented immunogenicity of Lewis lung carcinoma by infection with herpes simplex virus type 2

Ruth J. Reiss-Gutfreund*, Norbert R. Nowotny, Viktor Dostal, Heinrich Wrba

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


In vitro, LLT cells sustain HSV-2 replication without evidence of lysis. Simultaneously, multiplication of the cells is stimulated. These xenogenized cells were tested for their immunopotentiating capacity: three-step immunization with xenogenized viable cells conferred significantly augmented transplantation resistance to a challenge graft with 4 × 104 intact LLT cells. Latency periods preceding tumor formation were increased and 15% of the mice failed to form primary tumors. Metastatis was likewise decreased and 25% of the mice had healthy lungs. Immunopotentiation, however, did not suffice to significantly protect against a challenge with 6 × 104 intact cells. The presence of virus-specific neoantigens on HSV-2-infected vaiable cells was demonstrated by the progressively increasing number of rejections of 4 × 104 xenogenized cells during the successive immunization steps. Immunization with non-viable LLT cells did not augment resistance to challenge.

Original languageEnglish
Pages (from-to)523-531
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number6
Publication statusPublished - Jun 1982
Externally publishedYes

ASJC Scopus subject areas

  • Oncology


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