TY - JOUR
T1 - Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity
AU - Saeidi, Ayoub
AU - Nouri-Habashi, Akbar
AU - Razi, Omid
AU - Ataeinosrat, Ali
AU - Rahmani, Hiwa
AU - Mollabashi, Shirin Shirzad
AU - Bagherzadeh-Rahmani, Behnam
AU - Aghdam, Shahin Mahmoudi
AU - Khalajzadeh, Leila
AU - Al Kiyumi, Maisa Hamed
AU - Hackney, Anthony C.
AU - Laher, Ismail
AU - Heinrich, Katie M.
AU - Zouhal, Hassane
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/1/6
Y1 - 2023/1/6
N2 - The aim of this study was to investigate the effects of 12 weeks of high-intensity training with astaxanthin supplementation on adipokine levels, insulin resistance and lipid profiles in males with obesity. Sixty-eight males with obesity were randomly stratified into four groups of seventeen subjects each: control group (CG), supplement group (SG), training group (TG), and training plus supplement group (TSG). Participants underwent 12 weeks of treatment with astaxanthin or placebo (20 mg/d capsule daily). The training protocol consisted of 36 sessions of high-intensity functional training (HIFT), 60 min/sessions, and three sessions/week. Metabolic profiles, body composition, anthropometrical measurements, cardio-respiratory indices and adipokine [Cq1/TNF-related protein 9 and 2 (CTRP9 and CTRP2) levels, and growth differentiation factors 8 and 15 (GDF8 and GDF15)] were measured. There were significant differences for all indicators between the groups (p < 0.05). Post-hoc analysis indicated that the levels of CTRP9, CTRP2, and GDF8 were different from CG (p < 0.05), although levels of GDF15 were similar to CG (p > 0.05). Levels of GDF8 were similar in the SG and TG groups (p > 0.05), with reductions of GDF15 levels in both training groups (p < 0.05). A total of 12 weeks of astaxanthin supplementation and exercise training decreased adipokines levels, body composition (weight, %fat), anthropometrical factors (BMI), and improved lipid and metabolic profiles. These benefits were greater for men with obesity in the TSG group.
AB - The aim of this study was to investigate the effects of 12 weeks of high-intensity training with astaxanthin supplementation on adipokine levels, insulin resistance and lipid profiles in males with obesity. Sixty-eight males with obesity were randomly stratified into four groups of seventeen subjects each: control group (CG), supplement group (SG), training group (TG), and training plus supplement group (TSG). Participants underwent 12 weeks of treatment with astaxanthin or placebo (20 mg/d capsule daily). The training protocol consisted of 36 sessions of high-intensity functional training (HIFT), 60 min/sessions, and three sessions/week. Metabolic profiles, body composition, anthropometrical measurements, cardio-respiratory indices and adipokine [Cq1/TNF-related protein 9 and 2 (CTRP9 and CTRP2) levels, and growth differentiation factors 8 and 15 (GDF8 and GDF15)] were measured. There were significant differences for all indicators between the groups (p < 0.05). Post-hoc analysis indicated that the levels of CTRP9, CTRP2, and GDF8 were different from CG (p < 0.05), although levels of GDF15 were similar to CG (p > 0.05). Levels of GDF8 were similar in the SG and TG groups (p > 0.05), with reductions of GDF15 levels in both training groups (p < 0.05). A total of 12 weeks of astaxanthin supplementation and exercise training decreased adipokines levels, body composition (weight, %fat), anthropometrical factors (BMI), and improved lipid and metabolic profiles. These benefits were greater for men with obesity in the TSG group.
KW - adipokines
KW - astaxanthin
KW - cardiovascular risk factors
KW - high-intensity training
KW - obesity
KW - Body Composition
KW - Cardiovascular Diseases
KW - Humans
KW - Risk Factors
KW - Obesity/therapy
KW - Male
KW - Lipids
KW - Adipokines
KW - High-Intensity Interval Training
KW - Heart Disease Risk Factors
KW - Dietary Supplements
UR - http://www.scopus.com/inward/record.url?scp=85146670748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85146670748&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/07922a81-b64c-353d-97a3-ee2654d92585/
U2 - 10.3390/nu15020286
DO - 10.3390/nu15020286
M3 - Article
C2 - 36678157
AN - SCOPUS:85146670748
SN - 2072-6643
VL - 15
JO - Nutrients
JF - Nutrients
IS - 2
M1 - 286
ER -