Antiviral effects of statins

Armita M. Gorabi; Nasim Kiaie; Vanessa Bianconi; Tannaz Jamialahmadi; Khalid Al-Rasadi; Thomas P. Johnston; Matteo Pirro; Amirhossein Sahebkar

doi:10.1016/j.plipres.2020.101054

Antiviral effects of statins

Armita M. Gorabi, Nasim Kiaie, Vanessa Bianconi, Tannaz Jamialahmadi, Khalid Al-Rasadi, Thomas P. Johnston, Matteo Pirro^*, Amirhossein Sahebkar

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

Abstract

Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

Original language	English
Article number	101054
Journal	Progress in Lipid Research
Volume	79
DOIs	https://doi.org/10.1016/j.plipres.2020.101054
Publication status	Published - Jul 2020
Externally published	Yes

Keywords

Cholesterol
Infection
Pleiotropic
Statins
Virus

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.1016/j.plipres.2020.101054

Cite this

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title = "Antiviral effects of statins",

abstract = "Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.",

keywords = "Cholesterol, Infection, Pleiotropic, Statins, Virus",

author = "Gorabi, {Armita M.} and Nasim Kiaie and Vanessa Bianconi and Tannaz Jamialahmadi and Khalid Al-Rasadi and Johnston, {Thomas P.} and Matteo Pirro and Amirhossein Sahebkar",

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language = "English",

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TY - JOUR

T1 - Antiviral effects of statins

AU - Gorabi, Armita M.

AU - Kiaie, Nasim

AU - Bianconi, Vanessa

AU - Jamialahmadi, Tannaz

AU - Al-Rasadi, Khalid

AU - Johnston, Thomas P.

AU - Pirro, Matteo

AU - Sahebkar, Amirhossein

PY - 2020/7

Y1 - 2020/7

N2 - Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

AB - Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

KW - Cholesterol

KW - Infection

KW - Pleiotropic

KW - Statins

KW - Virus

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DO - 10.1016/j.plipres.2020.101054

M3 - Review article

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VL - 79

JO - Progress in Lipid Research

JF - Progress in Lipid Research

M1 - 101054

ER -

Antiviral effects of statins

Abstract

Keywords

ASJC Scopus subject areas

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