TY - JOUR
T1 - Antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of 'dimethyl dimethoxy biphenyl dicarboxylate' in male Wistar rats
AU - Abdallah, Heba M.I.
AU - Asaad, Gihan F.
AU - Arbid, Mahmoud S.
AU - Nomier, Yousra A.
N1 - Publisher Copyright:
© 2022 Journal of Advanced Pharmaceutical Technology & Research.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.
AB - Dimethyl dimethoxy biphenyl (DDB) dicarboxylate has been applied as a therapeutic modality for curing liver diseases, particularly hepatitis virus. The objective of this study was to assess the protective potential against Triton X-100 induced abnormal fat metabolism in addition to anti-inflammatory, analgesic, and antipyretic effects of DDB. The anti-inflammatory, antinociceptive, and antipyretic of DDB were investigated through induction of paw edema, pain, and fever in experimental rats. DDB decreased cholesterol and triglyceride contents. DDB resulted in inhibition of inflammation, nociception, and fever in the experimental models. DDB improved lipid profile, as evidence of hypolipidemic potential. It also showed anti-inflammatory, analgesic, and antipyretic properties.
KW - Analgesic
KW - Triton X-100
KW - anti-inflammatory
KW - antihyperlipidemic
KW - antipyretic
KW - dimethyl dimethoxy biphenyl dicarboxylate
UR - http://www.scopus.com/inward/record.url?scp=85129433929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129433929&partnerID=8YFLogxK
U2 - 10.4103/japtr.japtr_292_21
DO - 10.4103/japtr.japtr_292_21
M3 - Article
C2 - 35464660
AN - SCOPUS:85129433929
SN - 2231-4040
VL - 13
SP - 83
EP - 88
JO - Journal of Advanced Pharmaceutical Technology and Research
JF - Journal of Advanced Pharmaceutical Technology and Research
IS - 2
ER -
