Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation

P. Suyana; S. Nishanth Kumar; B. S.Dileep Kumar; Balagopal N. Nair; Suresh C. Pillai; A. Peer Mohamed; K. G.K. Warrier; U. S. Hareesh

doi:10.1039/c3ra46642f

Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation

P. Suyana, S. Nishanth Kumar, B. S.Dileep Kumar, Balagopal N. Nair, Suresh C. Pillai, A. Peer Mohamed, K. G.K. Warrier, U. S. Hareesh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of 300 μg ml^-1. The antifungal properties of zinc sulphide particles is attributed to the generation of reactive oxygen species due to the interaction of the nanoparticles with water. Additionally, the presence of Zn in the zone of inhibition and the absence of antifungal effects for large micron sized particles of ZnS suggest a size induced effect leading to perturbation of fungal cell membranes, resulting in growth inhibition.

Original language	English
Pages (from-to)	8439-8445
Number of pages	7
Journal	RSC Advances
Volume	4
Issue number	17
DOIs	https://doi.org/10.1039/c3ra46642f
Publication status	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation",

abstract = "Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of 300 μg ml-1. The antifungal properties of zinc sulphide particles is attributed to the generation of reactive oxygen species due to the interaction of the nanoparticles with water. Additionally, the presence of Zn in the zone of inhibition and the absence of antifungal effects for large micron sized particles of ZnS suggest a size induced effect leading to perturbation of fungal cell membranes, resulting in growth inhibition.",

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T1 - Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation

AU - Suyana, P.

AU - Kumar, S. Nishanth

AU - Kumar, B. S.Dileep

AU - Nair, Balagopal N.

AU - Pillai, Suresh C.

AU - Mohamed, A. Peer

AU - Warrier, K. G.K.

AU - Hareesh, U. S.

PY - 2014

Y1 - 2014

N2 - Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of 300 μg ml-1. The antifungal properties of zinc sulphide particles is attributed to the generation of reactive oxygen species due to the interaction of the nanoparticles with water. Additionally, the presence of Zn in the zone of inhibition and the absence of antifungal effects for large micron sized particles of ZnS suggest a size induced effect leading to perturbation of fungal cell membranes, resulting in growth inhibition.

AB - Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of 300 μg ml-1. The antifungal properties of zinc sulphide particles is attributed to the generation of reactive oxygen species due to the interaction of the nanoparticles with water. Additionally, the presence of Zn in the zone of inhibition and the absence of antifungal effects for large micron sized particles of ZnS suggest a size induced effect leading to perturbation of fungal cell membranes, resulting in growth inhibition.

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Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation

Abstract

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