TY - JOUR
T1 - An Evaluation of the Effectiveness of Repetitive Transcranial Magnetic Stimulation (rTMS) for the Management of Treatment-Resistant Depression with Somatic Attributes
T2 - A Hospital-Based Study in Oman
AU - Al-Ruhaili, Intisar
AU - Al-Huseini, Salim
AU - Al-Kaabi, Said
AU - Mahadevan, Sangeetha
AU - Al-Sibani, Nasser
AU - Al Balushi, Naser
AU - Islam, M Mazharul
AU - Jose, Sachin
AU - Mehr, Gilda Kiani
AU - Al-Adawi, Samir
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9/6
Y1 - 2023/9/6
N2 - Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression.
AB - Depressive illnesses in non-Western societies are often masked by somatic attributes that are sometimes impervious to pharmacological agents. This study explores the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for people experiencing treatment-resistant depression (TRD) accompanied by physical symptoms. Data were obtained from a prospective study conducted among patients with TRD and some somatic manifestations who underwent 20 sessions of rTMS intervention from January to June 2020. The Hamilton Rating Scale for Depression (HAMD) was used for clinical evaluation. Data were analysed using descriptive and inferential techniques (multiple logistic regression) in SPSS. Among the 49 participants (mean age: 42.5 ± 13.3), there was a significant reduction in posttreatment HAMD scores compared to baseline (t = 10.819, p < 0.0001, and 95% CI = 8.574–12.488), indicating a clinical response. Approximately 37% of the patients responded to treatment, with higher response rates among men and those who remained in urban areas, had a history of alcohol use, and were subjected to the standard 10 HZ protocol. After adjusting for all extraneous variables, the rTMS protocol emerged as the only significant predictor of response to the rTMS intervention. To our knowledge, this is the first study to examine the effectiveness of rTMS in the treatment of somatic depression.
KW - depressive illness
KW - Hamilton Rating Scale for Depression
KW - non-pharmacological approaches
KW - non-Western societies
KW - repetitive transcranial magnetic stimulation (rTMS)
KW - somatic attributes
KW - treatment-resistant depression (TRD)
UR - http://www.scopus.com/inward/record.url?scp=85172195568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85172195568&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/d5ac52a4-6793-3ac4-ad52-c0850499bf60/
U2 - 10.3390/brainsci13091289
DO - 10.3390/brainsci13091289
M3 - Article
C2 - 37759890
SN - 2076-3425
VL - 13
SP - 1289
JO - Brain Sciences
JF - Brain Sciences
IS - 9
M1 - 1289
ER -
