TY - JOUR
T1 - Ammonium Sulfate and Ultrafine Particle Affect early Onset of Alzheimer's Disease
AU - Kaumbekova, Samal
AU - Torkmahalleh, Mehdi Amouei
AU - Shah, Dhawal
N1 - Publisher Copyright:
Copyright © 2021, AIDIC Servizi S.r.l.
PY - 2021
Y1 - 2021
N2 - Recent environmental studies have shown the impact of air quality on human health and in particular, toxicological effect of particulate matter (PM) and ultrafine particles (UFPs) on progression of neurodegenerative diseases. While in-vivo experiments reveal enhanced concentration of amyloid beta peptides in the brains of animals after the exposure to PM and UFPs, the molecular interactions between peptides and atmospheric pollutants remain obscure. In this study, molecular dynamics simulations were performed to investigate the effect of UFPs on the aggregation of amyloid beta peptides, associated with the development of Alzheimer's Disease (AD) in human brain. In particular, the changes in the structure of eight Aβ16-21 peptides, the segment of Aβ1-42 peptide with the high propensity to aggregate were investigated. The aggregation kinetics of Aβ16-21 peptides and amount of beta sheets in their secondary structures were studied in the presence of varying concentrations of NH4+ and SO4-2 ions, common secondary inorganic ions found in the environmental realm from the different sources of atmospheric pollution. Moreover, the effect of hydrophobic UFP, modelled by C60 molecule, on the structure of peptides was analysed. The aggregation kinetics was calculated by estimating the time necessary to reach Solvent Accessible Surface Area (SASA) of peptides of 60 nm2. The study demonstrated that, although, the inhibitory effect of hydrophobic UFP on the formation of beta sheets was revealed, there could be a synergistic effect of the concentration of (NH4)2SO4 salt and presence of UFP on the aggregation kinetics of peptides. Among three different salt concentrations of 0.15 M, 0.25 M and 0.35 M, the slowest aggregation of peptides in the absence of C60 molecule and the fastest aggregation in the presence of C60 were observed at 0.25 M of (NH4)2SO4.
AB - Recent environmental studies have shown the impact of air quality on human health and in particular, toxicological effect of particulate matter (PM) and ultrafine particles (UFPs) on progression of neurodegenerative diseases. While in-vivo experiments reveal enhanced concentration of amyloid beta peptides in the brains of animals after the exposure to PM and UFPs, the molecular interactions between peptides and atmospheric pollutants remain obscure. In this study, molecular dynamics simulations were performed to investigate the effect of UFPs on the aggregation of amyloid beta peptides, associated with the development of Alzheimer's Disease (AD) in human brain. In particular, the changes in the structure of eight Aβ16-21 peptides, the segment of Aβ1-42 peptide with the high propensity to aggregate were investigated. The aggregation kinetics of Aβ16-21 peptides and amount of beta sheets in their secondary structures were studied in the presence of varying concentrations of NH4+ and SO4-2 ions, common secondary inorganic ions found in the environmental realm from the different sources of atmospheric pollution. Moreover, the effect of hydrophobic UFP, modelled by C60 molecule, on the structure of peptides was analysed. The aggregation kinetics was calculated by estimating the time necessary to reach Solvent Accessible Surface Area (SASA) of peptides of 60 nm2. The study demonstrated that, although, the inhibitory effect of hydrophobic UFP on the formation of beta sheets was revealed, there could be a synergistic effect of the concentration of (NH4)2SO4 salt and presence of UFP on the aggregation kinetics of peptides. Among three different salt concentrations of 0.15 M, 0.25 M and 0.35 M, the slowest aggregation of peptides in the absence of C60 molecule and the fastest aggregation in the presence of C60 were observed at 0.25 M of (NH4)2SO4.
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U2 - 10.3303/CET2185032
DO - 10.3303/CET2185032
M3 - Article
AN - SCOPUS:85109470925
SN - 1974-9791
VL - 85
SP - 187
EP - 192
JO - Chemical Engineering Transactions
JF - Chemical Engineering Transactions
ER -