Amlodipine: The double edged sword

Fatma Rabah, Mohamed El-Naggari, Dana Al-Nabhani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Aim: Amlodipine, a calcium channel blocker became one of the most popular antihypertensive medications used in the paediatric population. This is mainly due to its long half-life making it easy to use as a single daily dose. Amlodipine is associated with common side effects like flushing, headache and dizziness. The incidence of amlodipine-related oedema was noted to be lower in the paediatric population compared to adults. We emphasise the importance of monitoring the development of oedema in patients treated with amlodipine. Methods: Hereby, we report four paediatric cases with amlodipine-related generalised oedema. Conclusion: Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.

Original languageEnglish
Pages (from-to)540-542
Number of pages3
JournalJournal of Paediatrics and Child Health
Issue number6
Publication statusPublished - Jun 2017


  • amlodipine
  • oedema
  • paediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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