A stereospecific synthesis of tetra-substituted chiral piperazines

Raid J. Abdel-Jalil, Raed A. Al-Qawasmeh, Yousef Al-Abed, Wolfgang Voelter*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

Original languageEnglish
Pages (from-to)7703-7704
Number of pages2
JournalTetrahedron Letters
Issue number42
Publication statusPublished - Oct 15 1998
Externally publishedYes


  • Anhydro sugars
  • Chiral piperazines
  • Piperazine derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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