A rapid, mild, efficient, and solvent-free Friedel-Crafts acylation of N-acetyltetrahydroharmine

Sabira Begum; Syed Imran Hassan; Bina S. Siddiqui

doi:10.1081/SCC-200046479

A rapid, mild, efficient, and solvent-free Friedel-Crafts acylation of N-acetyltetrahydroharmine

Sabira Begum^*, Syed Imran Hassan, Bina S. Siddiqui

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The first solid-phase, rapid, and mild synthesis of 10-acyl and 12-acyl analogues of N-acetyltetrahydroharmine by Friedel-Crafts acylation has been developed. The products were obtained in high overall yields. The method also results in the high-yield synthesis of natural product jafrine.

Original language	English
Pages (from-to)	23-39
Number of pages	17
Journal	Synthetic Communications
Volume	35
Issue number	1
DOIs	https://doi.org/10.1081/SCC-200046479
Publication status	Published - 2005
Externally published	Yes

Keywords

Acyl N-acetyltetrahydroharmines
Friedel-Crafts acylation
N-acetyltetrahydroharmine
Solid-phase reaction
β-carboline

ASJC Scopus subject areas

Organic Chemistry

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10.1081/SCC-200046479

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abstract = "The first solid-phase, rapid, and mild synthesis of 10-acyl and 12-acyl analogues of N-acetyltetrahydroharmine by Friedel-Crafts acylation has been developed. The products were obtained in high overall yields. The method also results in the high-yield synthesis of natural product jafrine.",

keywords = "Acyl N-acetyltetrahydroharmines, Friedel-Crafts acylation, N-acetyltetrahydroharmine, Solid-phase reaction, β-carboline",

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AU - Begum, Sabira

AU - Hassan, Syed Imran

AU - Siddiqui, Bina S.

PY - 2005

Y1 - 2005

N2 - The first solid-phase, rapid, and mild synthesis of 10-acyl and 12-acyl analogues of N-acetyltetrahydroharmine by Friedel-Crafts acylation has been developed. The products were obtained in high overall yields. The method also results in the high-yield synthesis of natural product jafrine.

AB - The first solid-phase, rapid, and mild synthesis of 10-acyl and 12-acyl analogues of N-acetyltetrahydroharmine by Friedel-Crafts acylation has been developed. The products were obtained in high overall yields. The method also results in the high-yield synthesis of natural product jafrine.

KW - Acyl N-acetyltetrahydroharmines

KW - Friedel-Crafts acylation

KW - N-acetyltetrahydroharmine

KW - Solid-phase reaction

KW - β-carboline

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U2 - 10.1081/SCC-200046479

DO - 10.1081/SCC-200046479

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JF - Synthetic Communications

IS - 1

ER -

A rapid, mild, efficient, and solvent-free Friedel-Crafts acylation of N-acetyltetrahydroharmine

Abstract

Keywords

ASJC Scopus subject areas

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