TY - JOUR
T1 - A parametric study of the effect of arterial wall curvature on non-invasive assessment of stenosis severity
T2 - Computational fluid dynamics study
AU - Govindaraju, Kalimuthu
AU - Viswanathan, Girish N.
AU - Badruddin, Irfan Anjum
AU - Kamangar, Sarfaraz
AU - Salman Ahmed, N. J.
AU - Al-Rashed, Abdullah A.A.A.
PY - 2016/8/10
Y1 - 2016/8/10
N2 - The effect of coronary arterial wall curvature on noninvasive assessment of stenosis severity was studied by examining the fractional flow reserve (FFR), pressure drop coefficient (CDP) and lesion flow coefficient (LFC) under different angles of curvature of the arterial wall models. Computational simulation of hyperemic blood flow in curved arteries with different angles of curvature (0°, 30°, 60°, 90° and 120°) was developed in three severe categories of stenosis of 70% (moderate), 80% (intermediate), and 90% (severe) area stenoses (AS) to evaluate the effect of curvature on FFR, CDP and LFC. The numerical study showed that for a given percentage of AS, the curvature of the arterial wall augmented the flow resistance in addition to the resistance caused by the stenosis. Also, there are significant differences in FFR, CDP and LFC between a straight and a curved section. With an increase in artery wall curvature from 0° to 120°, FFR significantly decreases by 5%, 8% and 20% in 70%, 80% and 90% AS respectively. For a fixed stenosis severity, CDP significantly increases, whereas LFC decreases as the angle of curvature changes from straight to curved section. We conclude that the significant differences in FFR, CDP and LFC confirms that the functional significance of stenosis assessed non-invasively could lead to misjudgment of its severity. This will notably influence the intermediate stenosis severity. So the arterial wall curvature should be considered when assessing the significance of stenosis as an alternative to FFR.
AB - The effect of coronary arterial wall curvature on noninvasive assessment of stenosis severity was studied by examining the fractional flow reserve (FFR), pressure drop coefficient (CDP) and lesion flow coefficient (LFC) under different angles of curvature of the arterial wall models. Computational simulation of hyperemic blood flow in curved arteries with different angles of curvature (0°, 30°, 60°, 90° and 120°) was developed in three severe categories of stenosis of 70% (moderate), 80% (intermediate), and 90% (severe) area stenoses (AS) to evaluate the effect of curvature on FFR, CDP and LFC. The numerical study showed that for a given percentage of AS, the curvature of the arterial wall augmented the flow resistance in addition to the resistance caused by the stenosis. Also, there are significant differences in FFR, CDP and LFC between a straight and a curved section. With an increase in artery wall curvature from 0° to 120°, FFR significantly decreases by 5%, 8% and 20% in 70%, 80% and 90% AS respectively. For a fixed stenosis severity, CDP significantly increases, whereas LFC decreases as the angle of curvature changes from straight to curved section. We conclude that the significant differences in FFR, CDP and LFC confirms that the functional significance of stenosis assessed non-invasively could lead to misjudgment of its severity. This will notably influence the intermediate stenosis severity. So the arterial wall curvature should be considered when assessing the significance of stenosis as an alternative to FFR.
KW - Blood flow
KW - Computational fluid dynamics
KW - Non-invasive assessment
KW - Stenosis severity
KW - Straight and curved arteries
UR - http://www.scopus.com/inward/record.url?scp=84983034030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983034030&partnerID=8YFLogxK
U2 - 10.18520/cs/v111/i3/483-491
DO - 10.18520/cs/v111/i3/483-491
M3 - Article
AN - SCOPUS:84983034030
SN - 0011-3891
VL - 111
SP - 483
EP - 491
JO - Current Science
JF - Current Science
IS - 3
ER -