1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil*, M. Übele, W. Ehrlichmann, W. Voelter, H. J. Machulla

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number3
Publication statusPublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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