Changes of Prolactin Sensitivity in Gestational Diabetes

The hypothesis is that gestational diabetes (GDM) is characterized by a reduced sensitivity for the hormones prolactin (Prl) and placenta lactogen (PL). Both of these hormones act through the Prl receptor, a determinant of Prl sensitivity. In the project we aim to identify families where gestational diabetes is common. Blood from mothers with GDM will be used to determine the sequence of the Prl receptor with the intent to look for genetic differences in this receptor compared to women without GDM. The role of Prl will further be studied in cultured beta cells where the aim is to understand how certain genes (SOCS2/mTOR) and certain environmental components (palmitate) affect the Prl receptor sensitivity and beta cell functions. Prl has previously only been regarded to regulate fertility and lactation but new results demonstrate a broader function for this hormone that may include GDM. It is important to better define and prevent GDM because it has both short term and long term consequences for the child.