TY - JOUR
T1 - Xenomic networks variability and adaptation traits in wood decaying fungi
AU - Morel, Mélanie
AU - Meux, Edgar
AU - Mathieu, Yann
AU - Thuillier, Anne
AU - Chibani, Kamel
AU - Harvengt, Luc
AU - Jacquot, Jean-Pierre
AU - Gelhaye, Eric
N1 - © 2013 The Authors. Published by Society for Applied Microbiology and Blackwell Publishing Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
PY - 2013/5
Y1 - 2013/5
N2 - Fungal degradation of wood is mainly restricted to basidiomycetes, these organisms having developed complex oxidative and hydrolytic enzymatic systems. Besides these systems, wood-decaying fungi possess intracellular networks allowing them to deal with the myriad of potential toxic compounds resulting at least in part from wood degradation but also more generally from recalcitrant organic matter degradation. The members of the detoxification pathways constitute the xenome. Generally, they belong to multigenic families such as the cytochrome P450 monooxygenases and the glutathione transferases. Taking advantage of the recent release of numerous genomes of basidiomycetes, we show here that these multigenic families are extended and functionally related in wood-decaying fungi. Furthermore, we postulate that these rapidly evolving multigenic families could reflect the adaptation of these fungi to the diversity of their substrate and provide keys to understand their ecology. This is of particular importance for white biotechnology, this xenome being a putative target for improving degradation properties of these fungi in biomass valorization purposes.
AB - Fungal degradation of wood is mainly restricted to basidiomycetes, these organisms having developed complex oxidative and hydrolytic enzymatic systems. Besides these systems, wood-decaying fungi possess intracellular networks allowing them to deal with the myriad of potential toxic compounds resulting at least in part from wood degradation but also more generally from recalcitrant organic matter degradation. The members of the detoxification pathways constitute the xenome. Generally, they belong to multigenic families such as the cytochrome P450 monooxygenases and the glutathione transferases. Taking advantage of the recent release of numerous genomes of basidiomycetes, we show here that these multigenic families are extended and functionally related in wood-decaying fungi. Furthermore, we postulate that these rapidly evolving multigenic families could reflect the adaptation of these fungi to the diversity of their substrate and provide keys to understand their ecology. This is of particular importance for white biotechnology, this xenome being a putative target for improving degradation properties of these fungi in biomass valorization purposes.
KW - Adaptation, Physiological/genetics
KW - Basidiomycota/enzymology
KW - Biodegradation, Environmental
KW - Cytochrome P-450 Enzyme System/genetics
KW - Fungal Proteins/genetics
KW - Genome, Fungal
KW - Glutathione Transferase/genetics
KW - Metabolic Networks and Pathways/genetics
KW - Wood/chemistry
KW - Xenobiotics/metabolism
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U2 - 10.1111/1751-7915.12015
DO - 10.1111/1751-7915.12015
M3 - Review article
C2 - 23279857
SN - 1751-7907
VL - 6
SP - 248
EP - 263
JO - Microbial Biotechnology
JF - Microbial Biotechnology
IS - 3
ER -