TY - JOUR
T1 - WIN Gulf TAVR Registry
T2 - Describing Sex Differences in Patient Characteristics, Prognosis, and Outcomes
AU - Alasnag, Mirvat
AU - Alanazi, Nouf
AU - Al-Shaikh, Shereen
AU - AlMerri, Khaled
AU - Almoghairi, Abdulrahman
AU - Alenezi, Abdullah
AU - AlHarbi, Waleed
AU - Amin, Haitham
AU - Noor, Hussam
AU - Bardooli, Fawaz
AU - Al Lawati, Hatim
AU - Al Faraidy, Khalid
AU - AlShehri, Mohammed
AU - Thabane, Michael
AU - Thabane, Lehana
AU - Al-Shaibi, Khaled
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Background: Several international registries have examined outcomes in women undergoing transcatheter aortic valve replacement (TAVR). However, none of these studies included women from the Gulf region. The Women IN Gulf Transcatheter Aortic Valve Replacement (WIN Gulf TAVR) registry aimed to examine sex-based differences in patient characteristics and outcomes in patients undergoing TAVR in the region. Methods: This registry is a prespecified subanalysis of the main Gulf TAVR registry. Baseline characteristics, procedural details and success, and 1-year outcomes were recorded. The primary outcome consisted of a composite of all causes of death, myocardial infarction (MI), and rehospitalizations at 1 year. The secondary outcomes were a composite of the individual components of the primary composite. Results: A total of 347 women (44% of the Gulf TAVR registry) were included in the final analysis, with a mean age of 74.1 ± 9.1 years; mean ejection fraction of 56.20% ± 10.52%; and mean Society of Thoracic Surgeons score of 5.30 ± 4.35. The composite primary end point occurred in 12.4% (95% CI, 9.3-16.2). The individual components of the primary end point were as follows: death, 4.3% (95% CI, 2.6-7.0); MI, 1.1% (95% CI, 0.4-2.9); and rehospitalization, 9.8% (95% CI, 7.1-13.3), with 7.2% (95% CI, 4.9-10.4) related to cardiac causes. Conclusions: Women in the WIN Gulf TAVR registry had outcomes and baseline characteristics similar to men. Although higher rehospitalizations for cardiac causes and MI at 1 year in women were noted, the overall survival was better in women. These observations warrant a larger cohort to identify the drivers of events.
AB - Background: Several international registries have examined outcomes in women undergoing transcatheter aortic valve replacement (TAVR). However, none of these studies included women from the Gulf region. The Women IN Gulf Transcatheter Aortic Valve Replacement (WIN Gulf TAVR) registry aimed to examine sex-based differences in patient characteristics and outcomes in patients undergoing TAVR in the region. Methods: This registry is a prespecified subanalysis of the main Gulf TAVR registry. Baseline characteristics, procedural details and success, and 1-year outcomes were recorded. The primary outcome consisted of a composite of all causes of death, myocardial infarction (MI), and rehospitalizations at 1 year. The secondary outcomes were a composite of the individual components of the primary composite. Results: A total of 347 women (44% of the Gulf TAVR registry) were included in the final analysis, with a mean age of 74.1 ± 9.1 years; mean ejection fraction of 56.20% ± 10.52%; and mean Society of Thoracic Surgeons score of 5.30 ± 4.35. The composite primary end point occurred in 12.4% (95% CI, 9.3-16.2). The individual components of the primary end point were as follows: death, 4.3% (95% CI, 2.6-7.0); MI, 1.1% (95% CI, 0.4-2.9); and rehospitalization, 9.8% (95% CI, 7.1-13.3), with 7.2% (95% CI, 4.9-10.4) related to cardiac causes. Conclusions: Women in the WIN Gulf TAVR registry had outcomes and baseline characteristics similar to men. Although higher rehospitalizations for cardiac causes and MI at 1 year in women were noted, the overall survival was better in women. These observations warrant a larger cohort to identify the drivers of events.
KW - STS score
KW - TAVR
KW - aortic stenosis
KW - cardiovascular outcomes
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85160665887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85160665887&partnerID=8YFLogxK
U2 - 10.1016/j.jscai.2022.100509
DO - 10.1016/j.jscai.2022.100509
M3 - Article
AN - SCOPUS:85160665887
SN - 2772-9303
VL - 1
JO - Journal of the Society for Cardiovascular Angiography and Interventions
JF - Journal of the Society for Cardiovascular Angiography and Interventions
IS - 6
M1 - 100509
ER -